1. Gene
  2. ICMT - isoprenylcysteine carboxyl methyltransferase Gene

ICMT - isoprenylcysteine carboxyl methyltransferase Gene

Homo sapiens

Also known as PCMT; PPMT; PCCMT; HSTE14; MST098; MSTP098

Gene ID: 23463 | Gene type: protein coding

About ICMT

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,221,193-6,235,964 (from NCBI)

This gene has 4 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in kidney (RPKM 21.7), placenta (RPKM 18.3) and 25 other tissues.

Summary

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This Enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

ICMT Products(1)

mRNA Protein Name
NM_012405.4 NP_036537.1 protein-S-isoprenylcysteine O-methyltransferase

ICMT Protein Structure

ICMT

ICMT: Isoprenylcysteine carboxyl methyltransferase (ICMT) family (164 - 257)

  • 0
  • 100
  • 200
  • 284 a.a.
Protein Preferred Names Protein Names

protein-S-isoprenylcysteine O-methyltransferase

prenylated protein carboxyl methyltransferase

Related Diseases

Diseases Alias
Hyperhomocysteinemia
Familial Partial Lipodystrophy

Lipodystrophy, Familial Partial

Fpld

Kobberling-Dunnigan Syndrome

Dunnigan Syndrome

Koberling-Dunnigan Syndrome

Dunnigan-Kobberling Syndrome

Fpl

Familial Partial Lipodystrophy, Type 2

Hallermann-Streiff Syndrome

Francois Dyscephalic Syndrome

HSS

Hallermann'S Syndrome

Oculomandibulofacial Syndrome

Hallerman - Streiff Syndrome

François Dyscephalic Syndrome

Hallermann Streiff Francois Syndrome

Hallermann Streiff Syndrome

Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant

EDMD2

Autosomal Dominant Emery-Dreifuss Muscular Dystrophy

Emd2

Emery-Dreifuss Muscular Dystrophy, Autosomal Dominant

Scapuloilioperoneal Atrophy With Cardiopathy

Muscular Dystrophy With Early Contractures And Cardiomyopathy, Autosomal Dominant

Hauptmann-Thannhauser Muscular Dystrophy

Cardiomyopathy, Dilated, With Quadriceps Myopathy

Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 2

Muscular Dystrophy, Limb-Girdle, Type 1b

Muscular Dystrophy, Limb-Girdle, Type 1b, Formerly

Lgmd1b, Formerly

Muscular Dystrophy, Proximal, Type 1b, Formerly

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1b

Lgmd1b

Limb-Girdle Muscular Dystrophy 1b

Muscular Dystrophy, Proximal, Type 1b

Muscular Dystrophy With Early Contractures And Cardiomyopathy Autosomal Dominant

Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome

Cardiomyopathy, Dilated, 1a

Dilated Cardiomyopathy 1a

Cdcd1

CMD1A

Cardiomyopathy, Familial Idiopathic

Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation

Cardiomyopathy, Dilated, With Conduction Defect 1

Cardiomyopathy, Idiopathic Dilated

Cardiomyopathy, Congestive

Dilated Cardiomyopathy With Conduction Defect 1

Cardiomyopathy Dilated With Conduction Defect Type 1

Cardiomyopathy, Dilated 1a

Cardiomyopathy Dilated With Conduction Defect 1

Cardiomyopathy, Dilated, Type 1a

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus ICMT VGNC VGNC:67690
Macaca mulatta ICMT VGNC VGNC:73554
Bos taurus ICMT VGNC VGNC:30029
Mus musculus ICMT MGD MGI:1888594
Rattus norvegicus ICMT RGD RGD:621618