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ICMT - isoprenylcysteine carboxyl methyltransferase Gene

Also Known as PCMT; PPMT; PCCMT; HSTE14; MST098; MSTP098

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23463

About ICMT

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,221,193-6,235,964 (from NCBI)

This gene has 4 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in kidney (RPKM 21.7), placenta (RPKM 18.3) and 25 other tissues.

Summary

This gene encodes the third of three Enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in Other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

ICMT Products (1)

mRNA	Protein	Name
NM_012405.4	NP_036537.1	protein-S-isoprenylcysteine O-methyltransferase

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	IDA IDA: Inferred from direct assay	9614111	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	9614111	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ICMT Protein Structure

ICMT

0
100
200
284 a.a.

Protein Preferred Names	Protein Names
protein-S-isoprenylcysteine O-methyltransferase	prenylated protein carboxyl methyltransferase

ICMT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ICMT	O60725	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	ICMT	O60725	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	ICMT	O60725	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	ICMT	O60725	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	ICMT	O60725	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	ICMT	O60725	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	ICMT	O60725	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	ICMT	O60725	KCNJ6	Homo sapiens	P48051	Validated Y2H	32296183
Intra	ICMT	O60725	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	ICMT	O60725	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	ICMT	O60725	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	ICMT	O60725	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	ICMT	O60725	MUC1	Homo sapiens	P15941-11	Validated Y2H	32296183
Intra	ICMT	O60725	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	ICMT	O60725	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	ICMT	O60725	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	ICMT	O60725	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
Intra	ICMT	O60725	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	ICMT	O60725	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	ICMT	O60725	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	ICMT	O60725	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	ICMT	O60725	TRIM32	Homo sapiens	Q13049	Y2H Prey Pooling	32296183
Intra	ICMT	O60725	TRIM32	Homo sapiens	Q13049	Validated Y2H	32296183
Intra	ICMT	O60725	TRIM32	Homo sapiens	Q13049	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

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Hyperhomocysteinemia
Familial Partial Lipodystrophy	Lipodystrophy, Familial Partial Fpld Kobberling-Dunnigan Syndrome Dunnigan Syndrome Koberling-Dunnigan Syndrome Dunnigan-Kobberling Syndrome Fpl Familial Partial Lipodystrophy, Type 2
Hallermann-Streiff Syndrome	Francois Dyscephalic Syndrome HSS Hallermann'S Syndrome Oculomandibulofacial Syndrome Hallerman - Streiff Syndrome François Dyscephalic Syndrome Hallermann Streiff Francois Syndrome Hallermann Streiff Syndrome
Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant	EDMD2 Autosomal Dominant Emery-Dreifuss Muscular Dystrophy Emd2 Emery-Dreifuss Muscular Dystrophy, Autosomal Dominant Scapuloilioperoneal Atrophy With Cardiopathy Muscular Dystrophy With Early Contractures And Cardiomyopathy, Autosomal Dominant Hauptmann-Thannhauser Muscular Dystrophy Cardiomyopathy, Dilated, With Quadriceps Myopathy Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 2 Muscular Dystrophy, Limb-Girdle, Type 1b Muscular Dystrophy, Limb-Girdle, Type 1b, Formerly Lgmd1b, Formerly Muscular Dystrophy, Proximal, Type 1b, Formerly Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1b Lgmd1b Limb-Girdle Muscular Dystrophy 1b Muscular Dystrophy, Proximal, Type 1b Muscular Dystrophy With Early Contractures And Cardiomyopathy Autosomal Dominant
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Cardiomyopathy, Dilated, 1a	Dilated Cardiomyopathy 1a Cdcd1 CMD1A Cardiomyopathy, Familial Idiopathic Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation Cardiomyopathy, Dilated, With Conduction Defect 1 Cardiomyopathy, Idiopathic Dilated Cardiomyopathy, Congestive Dilated Cardiomyopathy With Conduction Defect 1 Cardiomyopathy Dilated With Conduction Defect Type 1 Cardiomyopathy, Dilated 1a Cardiomyopathy Dilated With Conduction Defect 1 Cardiomyopathy, Dilated, Type 1a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (67)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16160	Cysmethynil		99.07%	Unkown
HY-156500	ICMT-IN-1	Inhibitor	98.43%	Unkown
HY-118563	Farnesylthioacetic acid	Inhibitor	90.0%	Unkown
HY-149708	UCM-13207	Inhibitor	99.61%	Unkown
HY-155433	ICMT-IN-30	Inhibitor	/	Unkown
HY-157110	ICMT-IN-42	Inhibitor	/	Unkown
HY-155430	ICMT-IN-27	Inhibitor	/	Unkown
HY-149729	ICMT-IN-53	Inhibitor	/	Unkown
HY-157119	ICMT-IN-51	Inhibitor	/	Unkown
HY-149706	ICMT-IN-12	Inhibitor	/	Unkown
HY-155432	ICMT-IN-29	Inhibitor	/	Unkown
HY-155426	ICMT-IN-19	Inhibitor	/	Unkown
HY-155428	ICMT-IN-22	Inhibitor	/	Unkown
HY-157114	ICMT-IN-46	Inhibitor	/	Unkown
HY-157097	ICMT-IN-10	Inhibitor	/	Unkown
HY-155419	ICMT-IN-5	Inhibitor	/	Unkown
HY-149709	ICMT-IN-35	Inhibitor	/	Unkown
HY-157092B	(R)-ICMT-IN-3	Inhibitor	/	Unkown
HY-157108	ICMT-IN-40	Inhibitor	/	Unkown
HY-155424	ICMT-IN-15	Inhibitor	/	Unkown
HY-157100	ICMT-IN-23	Inhibitor	/	Unkown
HY-157092	ICMT-IN-3	Inhibitor	/	Unkown
HY-155427	ICMT-IN-20	Inhibitor	/	Unkown
HY-149730	ICMT-IN-54	Inhibitor	/	Unkown
HY-155418	ICMT-IN-2	Inhibitor	/	Unkown
HY-157107	ICMT-IN-39	Inhibitor	/	Unkown
HY-157118	ICMT-IN-50	Inhibitor	/	Unkown
HY-157092A	(S)-ICMT-IN-3	Inhibitor	/	Unkown
HY-157109	ICMT-IN-41	Inhibitor	/	Unkown
HY-157116	ICMT-IN-48	Inhibitor	/	Unkown
HY-149705	ICMT-IN-7	Inhibitor	/	Unkown
HY-157096	ICMT-IN-8	Inhibitor	/	Unkown
HY-157106	ICMT-IN-38	Inhibitor	/	Unkown
HY-157117	ICMT-IN-49	Inhibitor	/	Unkown
HY-157105	ICMT-IN-37	Inhibitor	/	Unkown
HY-157098	ICMT-IN-16	Inhibitor	/	Unkown
HY-157101	ICMT-IN-25	Inhibitor	/	Unkown
HY-157103	ICMT-IN-34	Inhibitor	/	Unkown
HY-155436	ICMT-IN-33	Inhibitor	/	Unkown
HY-157104	ICMT-IN-36	Inhibitor	/	Unkown
HY-155421	ICMT-IN-11	Inhibitor	/	Unkown
HY-157115	ICMT-IN-47	Inhibitor	/	Unkown
HY-155422	ICMT-IN-13	Inhibitor	/	Unkown
HY-157102	ICMT-IN-26	Inhibitor	/	Unkown
HY-157120	ICMT-IN-52	Inhibitor	/	Unkown
HY-157094	ICMT-IN-4	Inhibitor	/	Unkown
HY-157112	ICMT-IN-44	Inhibitor	/	Unkown
HY-157099	ICMT-IN-18	Inhibitor	/	Unkown
HY-155423	ICMT-IN-14	Inhibitor	/	Unkown
HY-155425	ICMT-IN-17	Inhibitor	/	Unkown
HY-155435	ICMT-IN-32	Inhibitor	/	Unkown
HY-155429	ICMT-IN-24	Inhibitor	/	Unkown
HY-155431	ICMT-IN-28	Inhibitor	/	Unkown
HY-155420	ICMT-IN-9	Inhibitor	/	Unkown
HY-155434	ICMT-IN-31	Inhibitor	/	Unkown
HY-157113	ICMT-IN-45	Inhibitor	/	Unkown
HY-157095	ICMT-IN-6	Inhibitor	/	Unkown
HY-149707	ICMT-IN-21	Inhibitor	/	Unkown
HY-157111	ICMT-IN-43	Inhibitor	/	Unkown
HY-149715	R1-11	Inhibitor	/	Unkown
HY-117776	CAY10677	Inhibitor	/	Unkown
HY-149710	POP-3MB	Inhibitor	/	Unkown
HY-149712	Spermatinamine	Inhibitor	/	Unkown
HY-149714	J6-3	Inhibitor	/	Unkown
HY-149711	Farnesylcysteine	Inhibitor	99.29%	Unkown
HY-149713	J1-1	Inhibitor	/	Unkown
HY-157206	ICMT-IN-55	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ICMT	VGNC	VGNC:67690
Macaca mulatta	ICMT	VGNC	VGNC:73554
Bos taurus	ICMT	VGNC	VGNC:30029
Mus musculus	ICMT	MGD	MGI:1888594
Rattus norvegicus	ICMT	RGD	RGD:621618
Others	ICMT	NCBI