1. PI3K/Akt/mTOR
  2. Akt
  3. Uprosertib

Uprosertib  (Synonyms: GSK2141795)

Cat. No.: HY-15965 Purity: 99.74%
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Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.

For research use only. We do not sell to patients.

Uprosertib Chemical Structure

Uprosertib Chemical Structure

CAS No. : 1047634-65-0

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10 mM * 1 mL in DMSO USD 145 In-stock
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10 mM * 1 mL
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10 mg USD 165 In-stock
50 mg USD 457 In-stock
100 mg USD 759 In-stock
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Customer Review

Based on 19 publication(s) in Google Scholar

Other Forms of Uprosertib:

Top Publications Citing Use of Products

    Uprosertib purchased from MCE. Usage Cited in: Oncotarget. 2018 Jul 31;9(59):31549-31558.  [Abstract]

    Western blots of the indicated proteins in the DMS114-P and DMS114-R cells treated with (+) and without (-) the AKT inhibitor, Uprosertib (200 nM) for 6 h (left panel) or 24 h (right panel). In the case of DMS114-P, extracts with (+) and without (-) treatment with PD173074 (1 µM) are also shown.

    Uprosertib purchased from MCE. Usage Cited in: Nat Commun. 2017 Sep 4;8(1):410.  [Abstract]

    Effect of EGFR TKIs and Akt inhibitors on key signal transduction proteins in parental and resistant PC9 cells. Western blot analysis of PC9 and PC9-ER treated for 4 h with Erlotinib (30 µM), GSK2141795 (2.5 µM) or the combination.

    Uprosertib purchased from MCE. Usage Cited in: Mol Cancer Ther. 2017 Apr;16(4):614-624.  [Abstract]

    Western blot analysis is performed with lysates from resistant cell lines treated either with vehicle (DMSO) or GSK2141795 (1 μM) for 24 hours to assess inhibition of Akt (pAKT) and downstream (pGSK3) signaling (three experimental replicates).

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    • Customer Review


    Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.

    IC50 & Target[1]


    38 nM (IC50)


    180 nM (IC50)


    328 nM (IC50)


    1570 nM (IC50)


    1850 nM (IC50)


    2100 nM (IC50)

    In Vitro

    Uprosertib (GSK2141795) inhibits Akt1/2/3 with the Kd values of 16/49/5 nM, respectively. Uprosertib potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts. Protein targets that bind Uprosertib (GSK2141795) in the lysate show a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug show no reduction in binding[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight






    CAS No.



    Room temperature in continental US; may vary elsewhere.


    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (116.48 mM; Need ultrasonic)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3296 mL 11.6482 mL 23.2964 mL
    5 mM 0.4659 mL 2.3296 mL 4.6593 mL
    10 mM 0.2330 mL 1.1648 mL 2.3296 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (5.82 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
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    Uprosertib Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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