2. Others Immunology/Inflammation NF-κB
  3. Isotope-Labeled Compounds COX NF-κB
  4. Guaiacol-d3

Guaiacol-d3  (Synonyms: 2-Methoxyphenol-d3)

Cat. No.: HY-N1380S1 Pureza: 98.67%
COA
SDS
Instrucciones de manejo Technical Support

Guaiacol-d3 is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

Guaiacol-d<sub>3</sub>

Guaiacol-d3 Estructura química

No. CAS : 74495-69-5

Tamaño Precio Stock Cantidad
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solution
10 mM * 1 mL in DMSO Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Liquid
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Other Forms of Guaiacol-d3:

Guaiacol-d3 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas COX:

Ver todas las isoformas
COX COX-1 COX-2 COX-3

Ver todos los productos específicos de isoformas NF-κB:

Ver todas las isoformas
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

Guaiacol-d3 is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Guaiacol-d3 Related Antibodies
Peso molecular

127.16

Fòrmula

C7H5D3O2
No. CAS
Unlabeled CAS
Appearance

Liquid (Density: 1.137 g/cm3)

Color

Light yellow to light brown

SMILES

OC1=CC=CC=C1OC([2H])([2H])[2H]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (786.41 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.8641 mL 39.3205 mL 78.6411 mL
5 mM 1.5728 mL 7.8641 mL 15.7282 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.0%

SDS (393 KB)

COA (252 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.8641 mL 39.3205 mL 78.6411 mL 196.6027 mL
5 mM 1.5728 mL 7.8641 mL 15.7282 mL 39.3205 mL
10 mM 0.7864 mL 3.9321 mL 7.8641 mL 19.6603 mL
15 mM 0.5243 mL 2.6214 mL 5.2427 mL 13.1068 mL
20 mM 0.3932 mL 1.9660 mL 3.9321 mL 9.8301 mL
25 mM 0.3146 mL 1.5728 mL 3.1456 mL 7.8641 mL
30 mM 0.2621 mL 1.3107 mL 2.6214 mL 6.5534 mL
40 mM 0.1966 mL 0.9830 mL 1.9660 mL 4.9151 mL
50 mM 0.1573 mL 0.7864 mL 1.5728 mL 3.9321 mL
60 mM 0.1311 mL 0.6553 mL 1.3107 mL 3.2767 mL
80 mM 0.0983 mL 0.4915 mL 0.9830 mL 2.4575 mL
100 mM 0.0786 mL 0.3932 mL 0.7864 mL 1.9660 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Guaiacol-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guaiacol-d374495-69-52-Methoxyphenol-d3Isotope-Labeled CompoundsCOXNF-κBCyclooxygenaseNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
Guaiacol-d3
Cat. No.:
HY-N1380S1
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.