Guaiacol-d₃ (Synonyms: 2-Methoxyphenol-d₃)

Cat. No.: HY-N1380S1 Purity: 98.67%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Guaiacol-d₃ 화학구조

CAS No. : 74495-69-5

사이즈	재고	수량
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	견적 받기 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	견적 받기 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
Liquid
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other Forms of Guaiacol-d₃:

Guaiacol In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All COX Isoform Specific Products:

View All Isoforms

COX COX-1 COX-2 COX-3

View All NF-κB Isoform Specific Products:

View All Isoforms

NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity^[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

127.16

화학식

C₇H₅D₃O₂

CAS No.

74495-69-5

Unlabeled CAS

90-05-1

Appearance

Liquid (Density: 1.137 g/cm³)

Color

Light yellow to light brown

SMILES

OC1=CC=CC=C1OC([2H])([2H])[2H]

선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 100 mg/mL (786.41 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.8641 mL	39.3205 mL	78.6411 mL
5 mM	1.5728 mL	7.8641 mL	15.7282 mL
10 mM	0.7864 mL	3.9321 mL	7.8641 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.0%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Murakami Y, et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and Guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res. 2007 Mar-Apr;27(2):801-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.8641 mL	39.3205 mL	78.6411 mL	196.6027 mL
	5 mM	1.5728 mL	7.8641 mL	15.7282 mL	39.3205 mL
	10 mM	0.7864 mL	3.9321 mL	7.8641 mL	19.6603 mL
	15 mM	0.5243 mL	2.6214 mL	5.2427 mL	13.1068 mL
	20 mM	0.3932 mL	1.9660 mL	3.9321 mL	9.8301 mL
	25 mM	0.3146 mL	1.5728 mL	3.1456 mL	7.8641 mL
	30 mM	0.2621 mL	1.3107 mL	2.6214 mL	6.5534 mL
	40 mM	0.1966 mL	0.9830 mL	1.9660 mL	4.9151 mL
	50 mM	0.1573 mL	0.7864 mL	1.5728 mL	3.9321 mL
	60 mM	0.1311 mL	0.6553 mL	1.3107 mL	3.2767 mL
	80 mM	0.0983 mL	0.4915 mL	0.9830 mL	2.4575 mL
	100 mM	0.0786 mL	0.3932 mL	0.7864 mL	1.9660 mL

Guaiacol-d₃ Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guaiacol-d₃74495-69-52-Methoxyphenol-d₃Isotope-Labeled CompoundsCOXNF-κBCyclooxygenaseNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Guaiacol-d3 (Synonyms: 2-Methoxyphenol-d3)

Other Forms of Guaiacol-d3:

Guaiacol-d3 Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All COX Isoform Specific Products:

View All NF-κB Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Guaiacol-d3 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Guaiacol-d3 Related Classifications