2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Guanidinoethyl sulfonate

Guanidinoethyl sulfonate  (Synonyms: Taurocyamine)

製品番号: HY-113329 純度: 99.91%
COA 取扱説明書 Technical Support

Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury.

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CAS 番号 : 543-18-0

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10 mM * 1 mL in Water
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10 mM * 1 mL in Water USD 55 在庫あり
Solid
50 mg $50 在庫あり
100 mg $80 在庫あり
250 mg $122 在庫あり
500 mg $170 在庫あり
1 g $240 在庫あり
5 g $514 在庫あり
10 g $720 在庫あり
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カスタマーレビュー

Based on 5 publication(s) in Google Scholar

Other Forms of Guanidinoethyl sulfonate:

Guanidinoethyl sulfonate 関連抗体

Top Publications Citing Use of Products

    Guanidinoethyl sulfonate purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):25.  [Abstract]

    The corneal epithelia of mice (3-month-old males) treated with oral Guanidinoethyl sulfonate, oral and topical Guanidinoethyl sulfonate, or control were stained with fluorescein sodium at 0, 24, 48, and 60 hours after wounding (left panel), and the corneal wound closure was presented as the percentage of the original wound.(1% Guanidinoethyl sulfonate was added to water 7 days prior to corneal epithelial debridement. Subsequently, using 100-mM Guanidinoethyl sulfonate eye drops or PBS five times daily for 3 days post-wounding.)

    Guanidinoethyl sulfonate purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):25.  [Abstract]

    Colony formation (left panel) and number (right panel) in Guanidinoethyl sulfonate (0-40 mM)-treated TKE2 cells.

    Guanidinoethyl sulfonate purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):25.  [Abstract]

    PCA analysis of TKE2 cells treated with Guanidinoethyl sulfonate versus control (CON) groups.

    Guanidinoethyl sulfonate purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):25.  [Abstract]

    KEGG analysis of upregulated/downregulated pathways in Guanidinoethyl sulfonate-treated TKE2 cells.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

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    製品説明

    Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    体外実験

    Electrophysiological experiments (Glycine receptor activity):
    Guanidinoethyl sulfonate (0.5 mM; transient) competitively antagonizes glycine-induced currents in mouse striatal neurons, shifting the glycine dose-response curve to the right, with the EC50 increasing from 62 μM (control group) to 154 μM (treated group)[1].
    Electrophysiological experiments (GABA receptor activity):
    Guanidinoethyl sulfonate (1 mM; transient) exhibits both weak agonist and antagonist effects on GABAA receptors in mouse striatal neurons[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Guanidinoethyl sulfonate 関連抗体

    Cell Viability Assay[1]

    Cell Line: Mouse striatal giant aspiny neurons (GAN) and medium spiny neurons (MSN)
    Concentration: 0.5 mM, 1 mM
    Incubation Time:
    Result: At 0.5 mM, shifted the glycine dose-response curve rightward without affecting maximal response, increasing EC50 from 62 μM to 154 μM and decreasing the Hill coefficient from 2.5 to 1.3.
    At 1 mM, reduced glycine (100 μM)-evoked currents to 36 ± 2.7% in GAN and 35 ± 3.9% in MSN, with voltage-independent block confirmed by unchanged reversal potentials near chloride equilibrium potential.
    体内実験

    Forebrain ischemia model:
    Guanidinoethyl sulfonate (625 mg/kg; intraperitoneal injection; once a day; 2 weeks) pretreatment in adult male gerbils significantly increases the survival rate of hippocampal CA1 neurons after ischemia and alleviates delayed neuronal death[2].
    Pregnancy model:
    Guanidinoethyl sulfonate (1% drinking water; free drinking; gestational day 11-21) causes a significant decrease in taurine concentrations in the fetus' body, liver, brain and placenta (32%-87%), reduces fetal body weight and organ weights, and increases maternal urinary taurine excretion in the Wistar pregnant rat model[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult male gerbils (70 g), forebrain ischemia-reperfusion model[2]
    Dosage: 625 mg/kg, dissolved in distilled water (neutralized to pH 7.0 with NaOH)
    Administration: Intraperitoneal injection, daily for 2 weeks, followed by 5-minute bilateral carotid artery occlusion and 7-day reperfusion
    Result: Significantly increased the number of surviving CA1 neurons (61.1 cells/mm) compared to saline-treated ischemic controls (17.75 cells/mm).
    Decreased brain taurine levels, while increased intracellular pH, indicating a protective effect against ischemic neuronal death without affecting baseline neuronal density in non-ischemic controls.
    Animal Model: Pregnant Wistar rats (initial weight 190-230 g), gestational taurine depletion model[3]
    Dosage: 1% guanidinoethyl sulfonate (GES) in drinking water
    Administration: Free access to GES-containing water from gestational day 11 to 21 (10 days total)
    Result: Led to significant taurine depletion in fetal tissues (54% in whole body, 37% in liver, 87% in brain, 32% in placenta) and maternal tissues (33% in liver, 32% in brain, 46% in plasma).
    Fetal wet weights of whole body, liver, brain, and placenta were reduced by 17%, 24%, 5%, and 13%, respectively, compared to controls.
    Maternal urinary taurine excretion increased significantly throughout the treatment period, with no changes in maternal organ weights or food/water intake.
    分子量

    167.19

    分子式

    C3H9N3O3S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N=C(NCCS(=O)(O)=O)N
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    H2O : 41.67 mg/mL (249.24 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.9812 mL 29.9061 mL 59.8122 mL
    5 mM 1.1962 mL 5.9812 mL 11.9624 mL
    10 mM 0.5981 mL 2.9906 mL 5.9812 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

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    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 25 mg/mL (149.53 mM); Clear solution; Need ultrasonic

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.91%

    COA (245 KB) HNMR (236 KB) RP-HPLC (242 KB) LCMS (89 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.9812 mL 29.9061 mL 59.8122 mL 149.5305 mL
    5 mM 1.1962 mL 5.9812 mL 11.9624 mL 29.9061 mL
    10 mM 0.5981 mL 2.9906 mL 5.9812 mL 14.9530 mL
    15 mM 0.3987 mL 1.9937 mL 3.9875 mL 9.9687 mL
    20 mM 0.2991 mL 1.4953 mL 2.9906 mL 7.4765 mL
    25 mM 0.2392 mL 1.1962 mL 2.3925 mL 5.9812 mL
    30 mM 0.1994 mL 0.9969 mL 1.9937 mL 4.9843 mL
    40 mM 0.1495 mL 0.7477 mL 1.4953 mL 3.7383 mL
    50 mM 0.1196 mL 0.5981 mL 1.1962 mL 2.9906 mL
    60 mM 0.0997 mL 0.4984 mL 0.9969 mL 2.4922 mL
    80 mM 0.0748 mL 0.3738 mL 0.7477 mL 1.8691 mL
    100 mM 0.0598 mL 0.2991 mL 0.5981 mL 1.4953 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Guanidinoethyl sulfonate Related Classifications

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    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Guanidinoethyl sulfonate543-18-0TaurocyamineEndogenous Metabolitetaurine transport antagonistInhibitorinhibitorinhibit

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