543-18-0
Chemical Structure
Guanidinoethyl sulfonate
Synonym(s): Taurocyamine
- CAS No.: 543-18-0
- Formula:C3H9N3O3S
- Molecular Weight:167.19
IUPAC Name: 2-guanidinoethane-1-sulfonic acid
InChIKey: JKLRIMRKZBSSED-UHFFFAOYSA-N
SMILES: N=C(NCCS(=O)(O)=O)N
Biological Activity: Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury[1][2][3].
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Guanidinoethyl sulfonate | 99.91% | Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury. | ||||||||||||||||||||
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Guanidinoethyl sulfonate (Standard) | 99.86% | Guanidinoethyl sulfonate (Standard) is the analytical standard of Guanidinoethyl sulfonate. This product is intended for research and analytical applications. Guanidinoethyl sulfonate is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury. | ||||||||||||||||||||
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- [1]. Sergeeva OA, et al. Guanidinoethyl sulphonate is a glycine receptor antagonist in striatum. Br J Pharmacol. 2002 Nov;137(6):855-60. [Content Brief]
- [2]. Igarashi H, et al. Guanidinoethane sulfate is neuroprotective towards delayed CA1 neuronal death in gerbils. Life Sci. 1995;56(14):1201-6. [Content Brief]
- [3]. K Ejiri, et al. Effect of guanidinoethyl sulfonate on taurine concentrations and fetal growth in pregnant rats. Biol Neonate. 1987;51(4):234-40. [Content Brief]
