2. Immunology/Inflammation
  3. NO Synthase
  4. Isosorbide dinitrate

Isosorbide dinitrate  (Synonyms: 二硝酸イソソルビド; ISDN)

製品番号: HY-B1409 純度: 99.89%
COA 取扱説明書 Technical Support

Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI).

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Isosorbide dinitrate

Isosorbide dinitrate 構造式

CAS 番号 : 87-33-2

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
5 mg $30 在庫あり
10 mg $48 在庫あり
25 mg $95 在庫あり
50 mg $155 在庫あり
100 mg $250 在庫あり
500 mg $550 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 0 publication(s) in Google Scholar

Other Forms of Isosorbide dinitrate:

Isosorbide dinitrate 関連抗体

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製品説明

Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI)[1].

Cellular Effect
Cell Line Type Value Description References
143B CC50
0.6 2
Compound: ISDN
In vitro cell cytotoxicity against 143-B cell lines (Human osteosarcoma cell line)
In vitro cell cytotoxicity against 143-B cell lines (Human osteosarcoma cell line)
[PMID: 12620076]
143B CC50
0.0006 41
Compound: ISDN
In vitro cell cytotoxicity against 143-B cell lines (Human osteosarcoma cell line)
In vitro cell cytotoxicity against 143-B cell lines (Human osteosarcoma cell line)
[PMID: 12620076]
143B CC50
0.0007 41
Compound: ISDN
In vitro cell cytotoxicity against 143B-LTK cell lines expressed in HSV-1 TK
In vitro cell cytotoxicity against 143B-LTK cell lines expressed in HSV-1 TK
[PMID: 12620076]
143B CC50
0.7 2
Compound: ISDN
In vitro cell cytotoxicity against 143B-LTK cell lines expressed in HSV-1 TK
In vitro cell cytotoxicity against 143B-LTK cell lines expressed in HSV-1 TK
[PMID: 12620076]
143B CC50
0.007 41
Compound: ISBN
In vitro cell cytotoxicity was determined against 143B cell line
In vitro cell cytotoxicity was determined against 143B cell line
[PMID: 15027876]
143B CC50
0.007 41
Compound: ISBN
In vitro cell cytotoxicity was determined against 143B cell line
In vitro cell cytotoxicity was determined against 143B cell line
[PMID: 15027876]
143B CC50
0.0074 41
Compound: ISBN
In vitro cell cytotoxicity was determined against 143B-LTK cell line
In vitro cell cytotoxicity was determined against 143B-LTK cell line
[PMID: 15027876]
143B CC50
0.0074 41
Compound: ISBN
In vitro cell cytotoxicity was determined against 143B-LTK cell line
In vitro cell cytotoxicity was determined against 143B-LTK cell line
[PMID: 15027876]
EMT6 CC50
0.38 2
Compound: ISBN
In vitro cell cytotoxicity was determined against EMT-6 cell line
In vitro cell cytotoxicity was determined against EMT-6 cell line
[PMID: 15027876]
KBALB cell line CC50
0.97 2
Compound: ISDN
In vitro cell cytotoxicity against KBALB cell line (transformed fibroblast sarcoma cell line)
In vitro cell cytotoxicity against KBALB cell line (transformed fibroblast sarcoma cell line)
[PMID: 12620076]
KBALB-STK CC50
0.65 2
Compound: ISDN
In vitro cell cytotoxicity against KBALB-STK cell lines expressed in HSV-1 TK
In vitro cell cytotoxicity against KBALB-STK cell lines expressed in HSV-1 TK
[PMID: 12620076]
EMT6 CC50
0.00038 41
Compound: ISBN
In vitro cell cytotoxicity was determined against EMT-6 cell line
In vitro cell cytotoxicity was determined against EMT-6 cell line
[PMID: 15027876]
KBALB-STK CC50
0.00065 41
Compound: ISDN
In vitro cell cytotoxicity against KBALB-STK cell lines expressed in HSV-1 TK
In vitro cell cytotoxicity against KBALB-STK cell lines expressed in HSV-1 TK
[PMID: 12620076]
KBALB-STK CC50
6.5 x 10-4 41
Compound: ISDN
In vitro cell cytotoxicity was determined against KBALB-STK cell line
In vitro cell cytotoxicity was determined against KBALB-STK cell line
[PMID: 15027876]
体内実験

Isosorbide dinitrate (3 mg/kg; intratracheal; for 13 days) improves pulmonary artery pressure and ventricular remodeling in a rat model of heart failure following myocardial infarction[1].
Isosorbide dinitrate postconditioning exhibits a cardioprotective effect against rat myocardial ischemia-reperfusion injury in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5–6 weeks old male juvenile Sprague-Dawley rats (200–250 g)[1]
Dosage: 3 mg/kg
Administration: Intratracheal; for 13 days following coronary ligation
Result: Reduced MI size and alleviated left and right ventricular remodeling following MI.
臨床実験
分子量

236.14

分子式

C6H8N2O8
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

[H][C@]12OC[C@H](O[N+]([O-])=O)[C@]1(OC[C@H]2O[N+]([O-])=O)[H]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (423.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2348 mL 21.1739 mL 42.3478 mL
5 mM 0.8470 mL 4.2348 mL 8.4696 mL
10 mM 0.4235 mL 2.1174 mL 4.2348 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (8.81 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (8.81 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.89%

COA (255 KB) HNMR (143 KB) RP-HPLC (79 KB) LCMS (86 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2348 mL 21.1739 mL 42.3478 mL 105.8694 mL
5 mM 0.8470 mL 4.2348 mL 8.4696 mL 21.1739 mL
10 mM 0.4235 mL 2.1174 mL 4.2348 mL 10.5869 mL
15 mM 0.2823 mL 1.4116 mL 2.8232 mL 7.0580 mL
20 mM 0.2117 mL 1.0587 mL 2.1174 mL 5.2935 mL
25 mM 0.1694 mL 0.8470 mL 1.6939 mL 4.2348 mL
30 mM 0.1412 mL 0.7058 mL 1.4116 mL 3.5290 mL
40 mM 0.1059 mL 0.5293 mL 1.0587 mL 2.6467 mL
50 mM 0.0847 mL 0.4235 mL 0.8470 mL 2.1174 mL
60 mM 0.0706 mL 0.3529 mL 0.7058 mL 1.7645 mL
80 mM 0.0529 mL 0.2647 mL 0.5293 mL 1.3234 mL
100 mM 0.0423 mL 0.2117 mL 0.4235 mL 1.0587 mL
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Isosorbide dinitrate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isosorbide dinitrate87-33-2ISDNNO SynthaseNitric oxide synthasesNOSmyocardialinfarctionNO,reperfusioninjuryInhibitorinhibitorinhibit

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製品名:
Isosorbide dinitrate
製品番号:
HY-B1409
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