2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Litoxetine

Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT3 receptor antagonist with a Ki of 85 nM for cerebral 5-HT3 receptors. Litoxetine is an antidepressant and has antiemetic properties.

Para uso exclusivo en investigación. No vendemos a pacientes.

Litoxetine

Litoxetine Estructura química

No. CAS : 86811-09-8

Tamaño Precio Stock Cantidad
1 mg Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
5 mg Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
10 mg Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
25 mg Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 mg Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 mg   Obtener un presupuesto  
200 mg   Obtener un presupuesto  
Synthetic products have potential research and development risk.

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Litoxetine Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas 5-HT Receptor:

Ver todas las isoformas
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT3 receptor antagonist with a Ki of 85 nM for cerebral 5-HT3 receptors. Litoxetine is an antidepressant and has antiemetic properties[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
1.3 μM
Compound: Litoxetine
Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cells
Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cells
[PMID: 19282174]
HEK293 IC50
1.4 μM
Compound: 4
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting
[PMID: 19740658]
HEK293 IC50
5.9 nM
Compound: 4
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting
[PMID: 19740658]
HEK293 IC50
6 nM
Compound: Litoxetine
Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cells
Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cells
[PMID: 19282174]
HEK293 IC50
6.5 μM
Compound: Litoxetine
Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cells
Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cells
[PMID: 19282174]
HEK293 IC50
6.7 μM
Compound: 4
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting
[PMID: 19740658]
Ensayo clínico
Peso molecular

241.33

Fòrmula

C16H19NO
No. CAS
SMILES

C1(COC2CCNCC2)=CC3=C(C=CC=C3)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Litoxetine Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Litoxetine86811-09-8SL 81.03855-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT3antidepressantantiemeticInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
Litoxetine
Cat. No.:
HY-106807
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.