MC-VA-PAB-Exatecan

Name: MC-VA-PAB-Exatecan
Brand: MedChemExpress
SKU: HY-147270
Rating: 4.5 (1 reviews)

Cat. No.: HY-147270 Purity: 98.88%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. MC-VA-PAB-Exatecan contains the ADC linker (peptide MC-VA-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631). MC-VA-PAB-Exatecan synthesized ADC shows good antitumor activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

MC-VA-PAB-Exatecan 화학구조

CAS No. : 2680543-57-9

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE MC-VA-PAB-Exatecan

•Patent. US20250255982A1.

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•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

View All Topoisomerase Isoform Specific Products:

View All Isoforms

Topoisomerase Topo I Topo II DNA gyrase

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Camptothecins

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

948.00

화학식

C₅₀H₅₄FN₇O₁₁

CAS No.

2680543-57-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

DMF : ≥ 100 mg/mL (105.49 mM)

DMSO : 100 mg/mL (105.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0549 mL	5.2743 mL	10.5485 mL
5 mM	0.2110 mL	1.0549 mL	2.1097 mL
10 mM	0.1055 mL	0.5274 mL	1.0549 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.01%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (258 KB) HNMR (574 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

References

[1]. KRAIEM, et al. Treatment of cancer. WO2021151984A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / DMSO	1 mM	1.0549 mL	5.2743 mL	10.5485 mL	26.3713 mL
	5 mM	0.2110 mL	1.0549 mL	2.1097 mL	5.2743 mL
	10 mM	0.1055 mL	0.5274 mL	1.0549 mL	2.6371 mL
	15 mM	0.0703 mL	0.3516 mL	0.7032 mL	1.7581 mL
	20 mM	0.0527 mL	0.2637 mL	0.5274 mL	1.3186 mL
	25 mM	0.0422 mL	0.2110 mL	0.4219 mL	1.0549 mL
	30 mM	0.0352 mL	0.1758 mL	0.3516 mL	0.8790 mL
	40 mM	0.0264 mL	0.1319 mL	0.2637 mL	0.6593 mL
	50 mM	0.0211 mL	0.1055 mL	0.2110 mL	0.5274 mL
	60 mM	0.0176 mL	0.0879 mL	0.1758 mL	0.4395 mL
	80 mM	0.0132 mL	0.0659 mL	0.1319 mL	0.3296 mL
	100 mM	0.0105 mL	0.0527 mL	0.1055 mL	0.2637 mL