2. PROTAC Apoptosis Immunology/Inflammation Cell Cycle/DNA Damage Stem Cell/Wnt
  3. PROTACs MDM-2/p53 IKZF Family Casein Kinase
  4. MD-4251

MD-4251 is an orally active MDM2 PROTAC degrader. MD-4251 potently degrades MDM2 in RS4;11 cells (DC50: 0.2 nM) and actives p53. MD-4251 shows strong antiproliferative activity against acute leukemia cells (wild-type p53) with minimal efficacy in mutant type. MD-4251 induces complete tumor regression in RS4;11 xenograft mice model. Pink: MDM2 ligand (HY-130684); Blue: CRBN ligase ligand (HY-W883326); Black: linker

Para uso exclusivo en investigación. No vendemos a pacientes.

MD-4251

MD-4251 Estructura química

Tamaño Precio Stock Cantidad
1 mg Obtener un presupuesto 11 - 13 weeks 10 - 12 weeks 12 - 14 weeks 10 - 12 weeks
5 mg Obtener un presupuesto 11 - 13 weeks 10 - 12 weeks 12 - 14 weeks 10 - 12 weeks
10 mg Obtener un presupuesto 11 - 13 weeks 10 - 12 weeks 12 - 14 weeks 10 - 12 weeks
25 mg Obtener un presupuesto 11 - 13 weeks 10 - 12 weeks 12 - 14 weeks 10 - 12 weeks
50 mg Obtener un presupuesto 11 - 13 weeks 10 - 12 weeks 12 - 14 weeks 10 - 12 weeks
100 mg   Obtener un presupuesto  
200 mg   Obtener un presupuesto  
Synthetic products have potential research and development risk.

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

MD-4251 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas PROTACs:

Ver todas las isoformas
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Ver todos los productos específicos de isoformas IKZF Family:

Ver todas las isoformas
IKZF1 IKZF2 IKZF3 IKZF4

Ver todos los productos específicos de isoformas Casein Kinase:

Ver todas las isoformas
CK1 CK2

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

MD-4251 is an orally active MDM2 PROTAC degrader. MD-4251 potently degrades MDM2 in RS4;11 cells (DC50: 0.2 nM) and actives p53. MD-4251 shows strong antiproliferative activity against acute leukemia cells (wild-type p53) with minimal efficacy in mutant type. MD-4251 induces complete tumor regression in RS4;11 xenograft mice model[1]. Pink: MDM2 ligand (HY-130684); Blue: CRBN ligase ligand (HY-W883326); Black: linker

IC50 & Target

MDM2

 

IKZF1

 

CK1α

 

Peso molecular

883.88

Fòrmula

C47H53Cl2FN8O4
SMILES

O=C1NC2=CC(Cl)=CC=C2[C@]13C4(CCCCC4)N[C@H]([C@@H]3C5=CC=CC(Cl)=C5F)C(N[C@@H]6CC[C@H](CC6)CN7CCN(CC7)C8=CC=C9C(N(N=C9C%10C(NC(CC%10)=O)=O)C)=C8)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MD-4251 Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD-4251MD4251MD 4251PROTACsMDM-2/p53IKZF FamilyCasein KinaseIkaros zinc finger protein familyPROTACDegradationMDM24T1 cellsRS4;11 cellsRS4;11 xenograft mice modelInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
MD-4251
Cat. No.:
HY-174458
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.