Mefenamic acid-d₄

Cat. No.: HY-B0574S Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Mefenamic acid-d₄ is a deuterium labeled Mefenamic acid. Mefenamic acid is a BBB-permeable non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC₅₀s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Mefenamic acid-d₄ 화학구조

CAS No. : 1216745-79-7

사이즈	재고	수량
1 mg	견적 받기 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	견적 받기 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
10 mg	견적 받기
50 mg	견적 받기

Synthetic products have potential research and development risk.

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* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Mefenamic acid-d₄:

Mefenamic acid In-stock

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•Related Small Molecules:

•Related Proteins:

View All COX Isoform Specific Products:

View All Isoforms

COX COX-1 COX-2 COX-3

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC₅₀ & Target^[1]

hCOX-1

40 nM (IC₅₀)

hCOX-2

3 nM (IC₅₀)

분자량

245.31

화학식

C₁₅H₁₁D₄NO₂

CAS No.

1216745-79-7

Unlabeled CAS

61-68-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=C(NC2=CC=CC(C)=C2C)C([2H])=C([2H])C([2H])=C1[2H]

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (407.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 0.1 mg/mL (0.41 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0765 mL	20.3824 mL	40.7647 mL
5 mM	0.8153 mL	4.0765 mL	8.1529 mL
10 mM	0.4076 mL	2.0382 mL	4.0765 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.0%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (256 KB) HNMR (215 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84. [Content Brief]

[2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0765 mL	20.3824 mL	40.7647 mL	101.9119 mL
	5 mM	0.8153 mL	4.0765 mL	8.1529 mL	20.3824 mL
	10 mM	0.4076 mL	2.0382 mL	4.0765 mL	10.1912 mL
	15 mM	0.2718 mL	1.3588 mL	2.7176 mL	6.7941 mL
	20 mM	0.2038 mL	1.0191 mL	2.0382 mL	5.0956 mL
	25 mM	0.1631 mL	0.8153 mL	1.6306 mL	4.0765 mL
	30 mM	0.1359 mL	0.6794 mL	1.3588 mL	3.3971 mL
	40 mM	0.1019 mL	0.5096 mL	1.0191 mL	2.5478 mL
	50 mM	0.0815 mL	0.4076 mL	0.8153 mL	2.0382 mL
	60 mM	0.0679 mL	0.3397 mL	0.6794 mL	1.6985 mL
	80 mM	0.0510 mL	0.2548 mL	0.5096 mL	1.2739 mL
	100 mM	0.0408 mL	0.2038 mL	0.4076 mL	1.0191 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.