2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. MPP+ iodide

MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT).

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CAS 番号 : 36913-39-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 40 在庫あり
Solution
10 mM * 1 mL in DMSO USD 40 在庫あり
Solid
10 mg $37 在庫あり
25 mg $78 在庫あり
50 mg $125 在庫あり
100 mg $200 在庫あり
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カスタマーレビュー

Based on 34 publication(s) in Google Scholar

Other Forms of MPP+ iodide:

MPP+ (iodide) 関連抗体

Top Publications Citing Use of Products

顧客検証

Cell Proliferation/Viability Assay
Cell Imaging/Staining
Apoptosis Analysis
Flow Cytometry
WB

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Jul 29;11(1):351.  [Abstract]

    SH-SY5Y cells were treated for 24 h with 1 μM MPP (MPP+ iodide). Bright field images of cells in the PD cell model.

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Jul 29;11(1):351.  [Abstract]

    SH-SY5Y cells were treated for 24 h with 1 μM MPP (MPP+ iodide). Representative images (left) and ratios (right) of TUNEL+ cells in PD cell model.

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Jul 29;11(1):351.  [Abstract]

    SH-SY5Y cells were treated for 24 h with 1 μM MPP (MPP+ iodide). Representative images of flow cytometric analysis of MMP in PD cell model (left), median fluorescence intensity (MFI; middle), and the proportion of high MMP (H-MMP) to total cell number (right).

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Nov 10;22(1):690.  [Abstract]

    CCK8 assay of SH-SY5Y cells treated with MPP+ (MPP+ iodide, 1 mM; 24 h) and purified melanin.

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Nov 10;22(1):690.  [Abstract]

    Typical JC-1 staining (Left) and TMRE staining (Right) of MPP+- (MPP+ iodide, 1 mM , 12 h) treated SH-SY5Y cells that were co-cultured with E. coli with distinct pretreatments.

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2023 Jul;48(7):2129-2137.  [Abstract]

    MPP+ iodide (MPP+; 0, 0.2, 0.4, 0.6, 0.8, 1, 2 mM; 48 h) decreases viability of SH-SY5Y cells (Fig D). At a concentration of 0.6 mM, MPP+ iodide decreases the cell viability by 25%. Moreover, the IC50 value of MPP+ iodide on SH-SY5Y cells is 1.233 mM (Fig C).

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2023 Jul;48(7):2129-2137.  [Abstract]

    MPP+ iodide (MPP+; 1.2 mM; 48 h) decreases TH, Prdx-2, SIRT1 protein levels and increases the ratio of Bax / Bcl-2, in SH-SY5Y cells.

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    製品説明

    MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    HEK293 EC50
    199 μM
    Compound: MPP+
    Inhibition of the Organic Cation Transporter 3 (OCT3, SLC22A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by MPP+ uptake in HEK-293 JumpIN-SLC22A3 cells (PubChem AID: 1745861)
    Inhibition of the Organic Cation Transporter 3 (OCT3, SLC22A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by MPP+ uptake in HEK-293 JumpIN-SLC22A3 cells (PubChem AID: 1745861)
    		[PMID: 35163125]
    体外実験

    MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells[1].
    MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    MPP+ (iodide) 関連抗体

    Cell Viability Assay[1]

    Cell Line: SH-SY5Y cells
    Concentration: 1, 2, 3 mM
    Incubation Time: 24 hours
    Result: SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner.
    分子量

    297.14

    分子式

    C12H12IN
    CAS 番号
    Appearance

    Solid

    Color

    Light yellow to orange

    SMILES

    C[N+]1=CC=C(C2=CC=CC=C2)C=C1.[I-]
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (336.54 mM; Need ultrasonic)

    DMSO : 100 mg/mL (336.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3654 mL 16.8271 mL 33.6542 mL
    5 mM 0.6731 mL 3.3654 mL 6.7308 mL
    10 mM 0.3365 mL 1.6827 mL 3.3654 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: 2.5 mg/mL (8.41 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    • Protocol 2

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (7.00 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (336.54 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.96%

    COA (249 KB) HNMR (225 KB) RP-HPLC (259 KB) MS (68 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 3.3654 mL 16.8271 mL 33.6542 mL 84.1354 mL
    5 mM 0.6731 mL 3.3654 mL 6.7308 mL 16.8271 mL
    10 mM 0.3365 mL 1.6827 mL 3.3654 mL 8.4135 mL
    15 mM 0.2244 mL 1.1218 mL 2.2436 mL 5.6090 mL
    20 mM 0.1683 mL 0.8414 mL 1.6827 mL 4.2068 mL
    25 mM 0.1346 mL 0.6731 mL 1.3462 mL 3.3654 mL
    30 mM 0.1122 mL 0.5609 mL 1.1218 mL 2.8045 mL
    40 mM 0.0841 mL 0.4207 mL 0.8414 mL 2.1034 mL
    50 mM 0.0673 mL 0.3365 mL 0.6731 mL 1.6827 mL
    60 mM 0.0561 mL 0.2805 mL 0.5609 mL 1.4023 mL
    80 mM 0.0421 mL 0.2103 mL 0.4207 mL 1.0517 mL
    100 mM 0.0337 mL 0.1683 mL 0.3365 mL 0.8414 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    MPP+ iodide Related Classifications

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    一般には略語で表示されます：C1V1 = C2V2

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MPP+36913-39-0Mitochondrial MetabolismdopaminergicneuronscomplexIrespiratorychainneurotoxicInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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