36913-39-0
Chemical Structure
MPP+ iodide
- CAS No.: 36913-39-0
- Formula:C12H12IN
- Molecular Weight:297.14
IUPAC Name: 1-methyl-4-phenylpyridin-1-ium iodide
InChIKey: RFDFRDXIIKROAI-UHFFFAOYSA-M
SMILES: C[N+]1=CC=C(C2=CC=CC=C2)C=C1.[I-]
Biological Activity: MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
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MPP+ iodide | 99.96% | MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT). | ||||||||||||||||||||
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MPP+ iodide (Standard) | ≥98% | MPP+ iodide (Standard) is the analytical standard of MPP+ iodide (HY-W008719). This product is intended for research and analytical applications. MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of ParKinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT). | ||||||||||||||||||||
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MPP+-d3 iodide | 99.21% | MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT). | ||||||||||||||||||||
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References
- [1]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394. [Content Brief]
- [2]. Martí Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45. [Content Brief]
