2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Drug Metabolite Potassium Channel
  4. N-Acetylprocainamide hydrochloride

N-Acetylprocainamide hydrochloride  (Synonyms: Acecainide hydrochloride; NAPA hydrochloride)

Cat. No.: HY-101433 Pureté: 99.83%
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N-Acetylprocainamide (Acecainide) hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias.

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N-Acetylprocainamide hydrochloride

N-Acetylprocainamide hydrochloride Chemical Structure

CAS No. : 34118-92-8

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Based on 1 publication(s) in Google Scholar

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N-Acetylprocainamide hydrochloride Related Antibodies

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Description

N-Acetylprocainamide (Acecainide) hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias[1][2][3].

In Vitro

N-Acetylprocainamide (32-160 nM) hydrochloride decreases the MFF of isolated rabbit right atria in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Acetylprocainamide hydrochloride Related Antibodies
In Vivo

N-Acetylprocainamide (30 mg/kg, i.v., over 15 min) hydrochloride restores sinus rhythm in anesthetized open-chest mongrel dogs with experimental atrial flutter induced by intercaval crush and rapid atrial pacing[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Experimental atrial flutter was induced in 15 anesthetized open-chest mongrel dogs (15-30 kg) by intercaval crush and rapid atrial pacing[3]
Dosage: 30 mg/kg
Administration: i.v., over 15 min
Result: Achieved atrial flutter conversion and atrial flutter reinduction prevention in anesthetized open-chest mongrel dogs.
Achieved significant prolongation of atrial effective refractory period, atrial functional refractory period, atrial flutter cycle length, and corrected QT interval.
Reduced the increment of atrial flutter cycle length in dogs.
Masse moléculaire

313.82

Formule

C15H24ClN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCN(CC)CC)C1=CC=C(NC(C)=O)C=C1.Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Pureté et documentation
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N-Acetylprocainamide hydrochloride Related Classifications

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Keywords:

N-Acetylprocainamide34118-92-8AcecainideNAPADrug MetabolitePotassium ChannelKcsAInhibitorinhibitorinhibit

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