1. Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
  2. Potassium Channel
    Drug Metabolite
  3. N-Acetylprocainamide

N-Acetylprocainamide (Synonyms: Acecainide; NAPA)

Cat. No.: HY-B1109 Purity: ≥98.0%
Handling Instructions

N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.

For research use only. We do not sell to patients.

N-Acetylprocainamide Chemical Structure

N-Acetylprocainamide Chemical Structure

CAS No. : 32795-44-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.

IC50 & Target

K+ channel[1]

In Vitro

N-Acetylprocainamide is a K+ blocker. N-Acetylprocainamide decreases the tensions induced by K+ and methacholine. The pIC50 values for N-acetylprocainamide against the contractions induced by 0.3 and 1 μM methacholine are 2.80 ± 0.03 and 2.65 ± 0.02, respectively. And such a relaxant effect of N-Acetylprocainamide is inhibited by K+ channel blockers[1]. N-Acetylprocainamide shows no effect on Na+ absorption or Cl- secretion[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

277.36

Formula

C₁₅H₂₃N₃O₂

CAS No.

32795-44-1

SMILES

O=C(NCCN(CC)CC)C1=CC=C(NC(C)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (360.54 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6054 mL 18.0271 mL 36.0542 mL
5 mM 0.7211 mL 3.6054 mL 7.2108 mL
10 mM 0.3605 mL 1.8027 mL 3.6054 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.01 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.01 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Keywords:

N-AcetylprocainamideAcecainide NAPAPotassium ChannelDrug MetaboliteKcsAInhibitorinhibitorinhibit

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N-Acetylprocainamide
Cat. No.:
HY-B1109
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