N-Acetylprocainamide hydrochloride
Based on 1 publication(s) in Google Scholar
N-Acetylprocainamide (Acecainide) hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 34118-92-8
- Formula: C15H24ClN3O2
- Molecular Weight:313.82
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) N-Acetylprocainamide hydrochloride
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Biological Activity
N-Acetylprocainamide (32-160 nM) hydrochloride decreases the MFF of isolated rabbit right atria in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Experimental atrial flutter was induced in 15 anesthetized open-chest mongrel dogs (15-30 kg) by intercaval crush and rapid atrial pacing[3]
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Dosage:30 mg/kg
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Administration:i.v., over 15 min
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Result:Achieved atrial flutter conversion and atrial flutter reinduction prevention in anesthetized open-chest mongrel dogs.
Achieved significant prolongation of atrial effective refractory period, atrial functional refractory period, atrial flutter cycle length, and corrected QT interval.
Reduced the increment of atrial flutter cycle length in dogs.
Chemical Information
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CAS No. 34118-92-8
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Appearance Solid
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Molecular Weight 313.82
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Formula C15H24ClN3O2
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Color White to off-white
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SMILES
O=C(NCCN(CC)CC)C1=CC=C(NC(C)=O)C=C1.Cl
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Synonyms
Acecainide hydrochloride; NAPA hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (1)
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Journal Impact Factor
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Most Recent
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ACS Omega
Computational Approaches to Identify Molecules Binding to Mycobacterium tuberculosis KasA. [Abstract]2020 Nov 15;5(46):29935-29942. PMID: 33251429
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Minchin RF, et al. Antiarrhythmic potency of procainamide and N-acetylprocainamide in rabbits. Eur J Pharmacol. 1978 Jan 1;47(1):51-6. [Content Brief]
[2]. Nakahara T, et al. Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle. Eur J Pharmacol. 2001 Mar 9;415(1):73-8. [Content Brief]
[3]. Okumura K, et al. Effects of N-acetylprocainamide on experimental atrial flutter and atrial electrophysiologic properties in conscious dogs with sterile pericarditis: comparison with the effects of quinidine. J Am Coll Cardiol. 1987 Jun;9(6):1332-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Acetylprocainamide hydrochloride Related Classifications
HY-101433 Related Classifications
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