2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. NAAD sodium

NAAD sodium  (Synonyms: Deamido nad sodium)

Cat. No.: HY-117029 Pureza: 99.15%
COA
SDS
Instrucciones de manejo Technical Support

NAAD sodium (Deamido nad sodium), a functional NAD+ precursor, is the substrate of glutamine-dependent NAD+ synthetase. NAAD sodium is used to study the structure of nicotinate mononucleotide adenylyltransferases.

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NAAD sodium

NAAD sodium Estructura química

No. CAS : 104809-30-5

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  

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Based on 1 publication(s) in Google Scholar

NAAD sodium Related Antibodies

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1 Publications Citing Use of MCE NAAD sodium

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Descripciòn

NAAD sodium (Deamido nad sodium), a functional NAD+ precursor, is the substrate of glutamine-dependent NAD+ synthetase. NAAD sodium is used to study the structure of nicotinate mononucleotide adenylyltransferases[1][2].

In Vitro

In peripheral blood mononuclear cells (PBMC), NAAD sodium is only expected to be produced in biosynthesis of NAD+ from tryptophan and NA2, was elevated from less than 20 nM to as high as 0.91 μM[1].
Nicotinamide adenine dinucleotide synthetases (NADS) catalyze the amidation of nicotinic acid adenine dinucleotide (NAAD) to yield the enzyme cofactor nicotinamide adenine dinucleotide (NAD)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NAAD sodium Related Antibodies
In Vivo

In mice, when nicotinic acid (NA) is provided by oral gavage, liver NA peaked (340 pmol/mg) in 15 min. Hepatic NA appearance is followed by an expected peak of 220 NAAD sodium at 1 h post gavage and a rise in hepatic NAD+ from 990 baseline to 2200 at 2 h[1].
NAAD sodium is reported in mouse liver when 500 mg/kg of radioactive nicotinamide (Nam) is injected intraperitoneally (IP) into the body cavity of mice. However, NAAD sodium is observed in kidneys, ovaries, lung, heart and brain in addition to liver in mice IP-injected with 500 mg/kg of NA but not Nam[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

686.39

Fòrmula

C21H25N6NaO15P2
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=P([O-])(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)[N+]2=CC=CC(C(O)=O)=C2)OP([O-])(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O)N4C=NC5=C(N=CN=C45)N)=O.[Na+]
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

H2O : 100 mg/mL (145.69 mM; Need ultrasonic)

DMSO : 10 mg/mL (14.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4569 mL 7.2845 mL 14.5690 mL
5 mM 0.2914 mL 1.4569 mL 2.9138 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1 mg/mL (1.46 mM); Clear solution

    This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1 mg/mL (1.46 mM); Clear solution

    This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 99.88%

SDS (393 KB)

COA (249 KB) HNMR (295 KB) RP-HPLC (245 KB) MS (67 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.4569 mL 7.2845 mL 14.5690 mL 36.4224 mL
5 mM 0.2914 mL 1.4569 mL 2.9138 mL 7.2845 mL
10 mM 0.1457 mL 0.7284 mL 1.4569 mL 3.6422 mL
H2O 15 mM 0.0971 mL 0.4856 mL 0.9713 mL 2.4282 mL
20 mM 0.0728 mL 0.3642 mL 0.7284 mL 1.8211 mL
25 mM 0.0583 mL 0.2914 mL 0.5828 mL 1.4569 mL
30 mM 0.0486 mL 0.2428 mL 0.4856 mL 1.2141 mL
40 mM 0.0364 mL 0.1821 mL 0.3642 mL 0.9106 mL
50 mM 0.0291 mL 0.1457 mL 0.2914 mL 0.7284 mL
60 mM 0.0243 mL 0.1214 mL 0.2428 mL 0.6070 mL
80 mM 0.0182 mL 0.0911 mL 0.1821 mL 0.4553 mL
100 mM 0.0146 mL 0.0728 mL 0.1457 mL 0.3642 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NAAD sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAAD104809-30-5Deamido nadEndogenous MetaboliteNAD+synthetasenicotinatemononucleotideadenylyltransferasesInhibitorinhibitorinhibit

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NAAD sodium
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