2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. NADH

NADH is an orally active dehydrogenase coenzyme that acts as a crucial electron carrier in cellular respiration and participates in ATP production. NADH promotes metabolism, supports brain function, and counteracts oxidative stress by transferring electrons to the electron transport chain. As a signaling molecule, NADH regulates multiple biological processes, including anti-apoptosis, synaptic plasticity, gene expression, and calcium homeostasis. Redox imbalance of NADH/NAD⁺ is one of the key pathological mechanisms of various diseases, such as diabetic nephropathy, neurodegenerative diseases, and ischemia-reperfusion injury.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (NADH disodium salt) that retains the same biological activity.

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NADH

NADH Estructura química

No. CAS : 58-68-4

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NADH Related Antibodies

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Descripciòn

NADH is an orally active dehydrogenase coenzyme that acts as a crucial electron carrier in cellular respiration and participates in ATP production. NADH promotes metabolism, supports brain function, and counteracts oxidative stress by transferring electrons to the electron transport chain. As a signaling molecule, NADH regulates multiple biological processes, including anti-apoptosis, synaptic plasticity, gene expression, and calcium homeostasis. Redox imbalance of NADH/NAD⁺ is one of the key pathological mechanisms of various diseases, such as diabetic nephropathy, neurodegenerative diseases, and ischemia-reperfusion injury.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

NADH (200 μM) reverses mitochondrial dysfunction and cell apoptosis in AIFM1 mutant稳转细胞系[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NADH Related Antibodies
Ensayo clínico
Peso molecular

665.44

Fòrmula

C21H29N7O14P2
No. CAS
SMILES

O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@@H](N3C=C(CC=C3)C(N)=O)[C@@H]([C@@H]2O)O)(O)=O)(O)=O)N4C5=NC=NC(N)=C5N=C4
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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NADH Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NADH58-68-4Endogenous MetaboliteApoptosisParkinson’s diseaseSIRT2Alzheimer’s diseasePARP-1SIRT1ryanodine receptorTRPM2 receptorHuntington’s diseaseglutathione reductasemitochondrial respiratory chain Complex IInhibitorinhibitorinhibit

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HY-113355
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