NADH disodium hydrate
Based on 10 publication(s) in Google Scholar
NADH disodium salt (Disodium NADH) hydrate is an orally active reduced coenzyme. NADH disodium salt hydrate is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt hydrate plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle.
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- CAS No.: 1949720-50-6
- Formula: C21H29N7O14P2.xH2O.2Na
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NADH disodium hydrate
More- Cell Mol Immunol. 2024 Jun;21(6):561-574. [Abstract]
- Food Chem. 2023 Oct 15:423:136274. [Abstract]
- Biomater Res. 2026 Apr 29.
- Free Radic Biol Med. 2025 Jan:226:56-69. [Abstract]
- J Ginseng Res. 2025 Sep;49(5):541-552. [Abstract]
- Mol Plant Pathol. 2025 Dec;26(12):e70196. [Abstract]
- Microorganisms. 2026 May 9;14(5):1070. [Abstract]
- Biochemistry. 2023 Dec 5;62(23):3396-3410. [Abstract]
- Chemrxiv. 2025 Aug 28.
- Research Square Preprint. 2023 Sep 15.
All Endogenous Metabolite Isoforms
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Biological Activity
NADH is unstable under acidic conditions but it is stable under alkaline conditions[2].
NADH (0-1 mM; 0-12 h) increases NAD+ levels in various mammalian cell lines[3].
NADH (1 mM; 24 h) causes low toxicity and protects cells from genotoxicity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
NADH (500 mg/kg; i.g.; once) promotes alcohol metabolism and prevents or ameliorates early liver injury caused by acute alcohol exposure in ethanol-loaded mice[3].
NADH (1000 mg/kg; i.p.; once) enhances tissue NAD+ levels in male C57BL/6J mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ICR mice[2]
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Dosage:5 μmol/mouse
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Administration:Intraperitoneal injection or oral administration, once
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Result:Produced significant increases in urinary excretions of nicotinamide (Nam) with intraperitoneal injection. Oral administration did not produce any increases in Nam or its metabolites.
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Animal Model:Male C57BL/6J mice[3]
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Dosage:500 mg/kg
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Administration:Intragastric administration, 15 min before ethanol administration
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Result:Significantly increased blood acetaldehyde levels in mice administered with alcohol between 30 min and two hours. Significantly reduced the acetaldehyde in the blood after two hours. Inhibited the decrease of NAD+/NADH redox ratio in hepatocytes.
Chemical Information
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CAS No. 1949720-50-6
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Formula C21H29N7O14P2.xH2O.2Na
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=C(C(N)=O)CC=C2)O[C@@H]1COP(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)(O[Na])=O)(O[Na])=O.O.[x]
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Synonyms
Disodium NADH hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (10)
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Journal Impact Factor
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Most Recent
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Cell Mol Immunol
2024 Jun;21(6):561-574. PMID: 38570588 -
Food Chem
Improvement of catalytic activity of sorbose dehydrogenase for deoxynivalenol degradation by rational design. [Abstract]2023 Oct 15:423:136274. PMID: 37159968 -
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Free Radic Biol Med
TSPO exacerbates sepsis-induced cardiac dysfunction by inhibiting p62-Mediated autophagic flux via the ROS-RIP1/RIP3-exosome axis. [Abstract]2025 Jan:226:56-69. PMID: 39542185 -
J Ginseng Res
Total ginsenosides and ginsenoside Rb2 delay hepatocyte senescence by regulating NAD+ metabolism and promoting IDO2/QPRT expression. [Abstract]2025 Sep;49(5):541-552. PMID: 40843012 -
Mol Plant Pathol
Negative Immune Regulator CAD7 Functions as a Small-Molecule Aldehyde Reductase and Increases Histamine Accumulation in Arabidopsis. [Abstract]2025 Dec;26(12):e70196. PMID: 41456913 -
Microorganisms
Characterization of RmlABCD Enzymes from Marine Bacteria and Efficient Synthesis of dTDP-L-Rhamnose. [Abstract]2026 May 9;14(5):1070. PMID: 42197457 -
Biochemistry
Full-Length NAD+-I Riboswitches Bind a Single Cofactor but Cannot Discriminate against Adenosine Triphosphate. [Abstract]2023 Dec 5;62(23):3396-3410. PMID: 37947391 -
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Purity & Documentation
References
[1]. Ying W. NAD+ and NADH in cellular functions and cell death. Front Biosci. 2006 Sep 1;11:3129-48. [Content Brief]
[2]. Kimura N, et al. Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH. J Nutr Sci Vitaminol (Tokyo). 2006 Apr;52(2):142-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NADH disodium hydrate Related Classifications
HY-F0001A Related Classifications
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