Naloxonazine dihydrochloride 

Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC₅₀ of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity^[1][2][3].

Naloxonazine is relatively stable in solution^[2].
Naloxonazine (72 h) is active against the intracellular amastigote stage of Leishmania donovani with a half maximal inhibitory concentration (GI₅₀) of 3.45 μM^[3].
Naloxonazine (10 μM; 0-72 h) is active at early stages of Leishmania donovani infection^[3].
Naloxonazine affects acidic compartments of the host cell which in turn limit L. donovani intracellular growth^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Naloxonazine (20 mg/kg; i.p.; once) attenuates the increment of locomotor activity induced by acute methamphetamine in mice^[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

723.69

Solid

C₃₈H₄₄Cl₂N₄O₆

880759-65-9

O[[email protected]@]([[email protected]@]1([H])CC2=CC=C3O)(CC/4)[[email protected]@]5(CCN1CC=C)C2=C3O[[email protected]@]5([H])C4=N\N=C(CC[[email protected]]67O)\[[email protected]@]8([H])[[email protected]]6(CCN(CC=C)[[email protected]]7([H])CC9=CC=C%10O)C9=C%10O8.Cl.Cl

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Chien CC, et al. Naloxonazine, a specific mu-opioid receptor antagonist, attenuates the increment of locomotor activity induced by acute methamphetamine in mice. Toxicol Lett. 2012 Jul 7;212(1):61-5.  [Content Brief]

  [2]. Hahn EF, et al. Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites. Life Sci. 1982 Sep 20-27;31(12-13):1385-8.  [Content Brief]

  [3]. De Muylder G, et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10(12):e0005234.  [Content Brief]