Naloxonazine
Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 82824-01-9
- 分子式: C38H42N4O6
- 分子量:650.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Leishmania |
Naloxonazine(0-50 μM, 24-72 h) shows inhibitory activity against the astigmatic phase of Leishmania donovani, and its maximum inhibitory concentration the GI50 value is 3.45 μM. The GI50 of THP-1 host cells is 34 μM[1].
Naloxonazine(10 μM, 4-72 h) inhibits the intracellular growth of the parasite by 70% after 24 h treatment and 95% after 72 h treatment[1].
Naloxonazine(10 μM, 4 or 24-72 h) leads to upregulation of vATPase subunits (ATP6V0C and TCIRG1) and actin (ACTB) genes and proteins, and affects the intracellular acid compartment of host cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 82824-01-9
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分子量 650.76
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分子式 C38H42N4O6
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SMILES
O[C@@]1(CC/2)[C@@]([C@](O3)([H])C2=N\N=C(CC4)\[C@@](OC5=C6O)([H])[C@]7(CCN8CC=C)C5=C(C=C6)C[C@]8([H])[C@@]74O)(CC9)C(C3=C%10O)=C(C=C%10)C[C@@]1([H])N9CC=C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Géraldine De Muylder, et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10(12):e0005234. [Content Brief]
[2]. Roberto Ciccocioppo, et al. Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology. 2002 Sep;27(3):391-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Naloxonazine 関連分類
HY-137180 関連分類
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