Naloxonazine
Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function.
For research use only. We do not sell to patients.
- CAS No.: 82824-01-9
- Formula: C38H42N4O6
- Molecular Weight:650.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Leishmania |
Naloxonazine(0-50 μM, 24-72 h) shows inhibitory activity against the astigmatic phase of Leishmania donovani, and its maximum inhibitory concentration the GI50 value is 3.45 μM. The GI50 of THP-1 host cells is 34 μM[1].
Naloxonazine(10 μM, 4-72 h) inhibits the intracellular growth of the parasite by 70% after 24 h treatment and 95% after 72 h treatment[1].
Naloxonazine(10 μM, 4 or 24-72 h) leads to upregulation of vATPase subunits (ATP6V0C and TCIRG1) and actin (ACTB) genes and proteins, and affects the intracellular acid compartment of host cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 82824-01-9
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Molecular Weight 650.76
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Formula C38H42N4O6
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SMILES
O[C@@]1(CC/2)[C@@]([C@](O3)([H])C2=N\N=C(CC4)\[C@@](OC5=C6O)([H])[C@]7(CCN8CC=C)C5=C(C=C6)C[C@]8([H])[C@@]74O)(CC9)C(C3=C%10O)=C(C=C%10)C[C@@]1([H])N9CC=C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Géraldine De Muylder, et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10(12):e0005234. [Content Brief]
[2]. Roberto Ciccocioppo, et al. Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology. 2002 Sep;27(3):391-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Naloxonazine Related Classifications
HY-137180 Related Classifications
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