Naloxonazine
Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function.
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- CAS. Nr.: 82824-01-9
- Formel: C38H42N4O6
- Molecular Weight:650.76
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
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Leishmania |
In Vitro
Naloxonazine(0-50 μM, 24-72 h) shows inhibitory activity against the astigmatic phase of Leishmania donovani, and its maximum inhibitory concentration the GI50 value is 3.45 μM. The GI50 of THP-1 host cells is 34 μM[1].
Naloxonazine(10 μM, 4-72 h) inhibits the intracellular growth of the parasite by 70% after 24 h treatment and 95% after 72 h treatment[1].
Naloxonazine(10 μM, 4 or 24-72 h) leads to upregulation of vATPase subunits (ATP6V0C and TCIRG1) and actin (ACTB) genes and proteins, and affects the intracellular acid compartment of host cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 82824-01-9
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Molecular Weight 650.76
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Formel C38H42N4O6
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SMILES
O[C@@]1(CC/2)[C@@]([C@](O3)([H])C2=N\N=C(CC4)\[C@@](OC5=C6O)([H])[C@]7(CCN8CC=C)C5=C(C=C6)C[C@]8([H])[C@@]74O)(CC9)C(C3=C%10O)=C(C=C%10)C[C@@]1([H])N9CC=C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Géraldine De Muylder, et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10(12):e0005234. [Content Brief]
[2]. Roberto Ciccocioppo, et al. Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology. 2002 Sep;27(3):391-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Naloxonazine Related Classifications
HY-137180 Related Classifications
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