2. Antibody-drug Conjugate/ADC Related Metabolic Enzyme/Protease
  3. ADC Payload N-myristoyltransferase
  4. NMT-IN-7

NMT-IN-7 is a N-myristoyl transferase (NMT) inhibitor, with IC50s of 2.1 nM for HsNMT1M, 0.6 nM for SU-DHL-10 cell. NMT-IN-7 can be used as a ADC cytotoxin.

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NMT-IN-7

NMT-IN-7 Chemische Struktur

CAS. Nr. : 3032302-70-5

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NMT-IN-7 Related Antibodies

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Beschreibung

NMT-IN-7 is a N-myristoyl transferase (NMT) inhibitor, with IC50s of 2.1 nM for HsNMT1M, 0.6 nM for SU-DHL-10 cell. NMT-IN-7 can be used as a ADC cytotoxin[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NMT-IN-7 Related Antibodies
Molekulargewicht

497.58

Formel

C27H33F2N5O2
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C(F)C(OCCC2=C(C)N(C)N=C2C(C(C)(C)C)O)=C(C3=CN4C(CNC)=CN=C4C=C3)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (251.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0097 mL 10.0486 mL 20.0973 mL
5 mM 0.4019 mL 2.0097 mL 4.0195 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 98.83%

SDS (252 KB)

COA (260 KB) HNMR (283 KB) LCMS (102 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0097 mL 10.0486 mL 20.0973 mL 50.2432 mL
5 mM 0.4019 mL 2.0097 mL 4.0195 mL 10.0486 mL
10 mM 0.2010 mL 1.0049 mL 2.0097 mL 5.0243 mL
15 mM 0.1340 mL 0.6699 mL 1.3398 mL 3.3495 mL
20 mM 0.1005 mL 0.5024 mL 1.0049 mL 2.5122 mL
25 mM 0.0804 mL 0.4019 mL 0.8039 mL 2.0097 mL
30 mM 0.0670 mL 0.3350 mL 0.6699 mL 1.6748 mL
40 mM 0.0502 mL 0.2512 mL 0.5024 mL 1.2561 mL
50 mM 0.0402 mL 0.2010 mL 0.4019 mL 1.0049 mL
60 mM 0.0335 mL 0.1675 mL 0.3350 mL 0.8374 mL
80 mM 0.0251 mL 0.1256 mL 0.2512 mL 0.6280 mL
100 mM 0.0201 mL 0.1005 mL 0.2010 mL 0.5024 mL
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NMT-IN-7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NMT-IN-73032302-70-5ADC PayloadN-myristoyltransferaseADC CytotoxinNMTSU-DHL-10cytotoxinInhibitorinhibitorinhibit

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SAFETY DATA SHEET (SDS)

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