2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. (E)-Crotonic acid

クロトン酸  (Synonyms: Crotonic acid; (E)-2-Butenoic acid; (E)-Crotonic acid; trans-2-Butenoic acid; trans-Crotonic acid; NSC 8751)

製品番号: HY-Y1644 純度: 99.69%
COA 取扱説明書 Technical Support

NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives.

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(E)-Crotonic acid

クロトン酸 構造式

CAS 番号 : 107-93-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in Water USD 33 在庫あり
Solid
500 mg $30 在庫あり
5 g $40 在庫あり
10 g $50 在庫あり
25 g $65 在庫あり
50 g $80 在庫あり
100 g $95 在庫あり
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Based on 1 publication(s) in Google Scholar

Other Forms of (E)-Crotonic acid:

クロトン酸 関連抗体

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製品説明

NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives[1][2].

体外実験

NSC 8751 can be used to evaluate the skin sensitization and toxicological safety of structurally similar unsaturated carboxylic acid fragrances (such as 2-methyl-trans-2-butenoic acid). For example, the human repeated patch test (HRIPT) and local lymph node assay can be used to confirm the safety of similar substances in cosmetics[1].
Or the toxicological data of NSC 8751 can be used to deduce the safety of similar compounds through cross-species and structural analogies. For example, based on the non-sensitizing property of NSC 8751, the safety assessment of 2-methyl-trans-2-butenoic acid in cosmetics can be supported[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

クロトン酸 関連抗体
分子量

86.09

分子式

C4H6O2
CAS 番号
Appearance

Solid

Color

White to yellow

SMILES

C/C=C/C(O)=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Store at room temperature 3 years

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature 3 years)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (1161.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 11.6158 mL 58.0788 mL 116.1575 mL
5 mM 2.3232 mL 11.6158 mL 23.2315 mL
10 mM 1.1616 mL 5.8079 mL 11.6158 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.71%

COA (245 KB) HNMR (112 KB) GC (211 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 11.6158 mL 58.0788 mL 116.1575 mL 290.3938 mL
5 mM 2.3232 mL 11.6158 mL 23.2315 mL 58.0788 mL
10 mM 1.1616 mL 5.8079 mL 11.6158 mL 29.0394 mL
15 mM 0.7744 mL 3.8719 mL 7.7438 mL 19.3596 mL
20 mM 0.5808 mL 2.9039 mL 5.8079 mL 14.5197 mL
25 mM 0.4646 mL 2.3232 mL 4.6463 mL 11.6158 mL
30 mM 0.3872 mL 1.9360 mL 3.8719 mL 9.6798 mL
40 mM 0.2904 mL 1.4520 mL 2.9039 mL 7.2598 mL
50 mM 0.2323 mL 1.1616 mL 2.3232 mL 5.8079 mL
60 mM 0.1936 mL 0.9680 mL 1.9360 mL 4.8399 mL
80 mM 0.1452 mL 0.7260 mL 1.4520 mL 3.6299 mL
100 mM 0.1162 mL 0.5808 mL 1.1616 mL 2.9039 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(E)-Crotonic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-Crotonic acid107-93-7(E)-2-Butenoic acid trans-2-Butenoic acid trans-Crotonic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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