2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Nucleoside Antimetabolite/Analog Endogenous Metabolite
  4. Orotic acid-13C,15N2 monohydrate

Orotic acid-13C,15N2 monohydrate  (Synonyms: 6-Carboxyuracil-13C,15N2 monohydrate; Vitamin B13-13C,15N2 monohydrate)

Cat. No.: HY-N0157S1 Pureza: 99.93%
COA
SDS
Instrucciones de manejo Technical Support

Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats.

Para uso exclusivo en investigación. No vendemos a pacientes.

Orotic acid-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub> monohydrate

Orotic acid-13C,15N2 monohydrate Estructura química

No. CAS : 1346602-15-0

Tamaño Precio Stock Cantidad
1 mg En stock
5 mg   Obtener un presupuesto  
10 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Other Forms of Orotic acid-13C,15N2 monohydrate:

Orotic acid-13C,15N2 monohydrate Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Endogenous Metabolite:

Ver todas las isoformas
Human Endogenous Metabolite Microbial Metabolite

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Orotic acid-13C,15N2 monohydrate Related Antibodies
Peso molecular

177.09

Fòrmula

C413CH615N2O5
No. CAS
Unlabeled CAS
Appearance

Solid

Color

White to light yellow

SMILES

OC(C1=CC([15NH][13C]([15NH]1)=O)=O)=O.O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : 55 mg/mL (310.58 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6468 mL 28.2342 mL 56.4685 mL
5 mM 1.1294 mL 5.6468 mL 11.2937 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.93%

SDS (252 KB)

COA (251 KB) Elemental Analysis Report (110 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.6468 mL 28.2342 mL 56.4685 mL 141.1712 mL
5 mM 1.1294 mL 5.6468 mL 11.2937 mL 28.2342 mL
10 mM 0.5647 mL 2.8234 mL 5.6468 mL 14.1171 mL
15 mM 0.3765 mL 1.8823 mL 3.7646 mL 9.4114 mL
20 mM 0.2823 mL 1.4117 mL 2.8234 mL 7.0586 mL
25 mM 0.2259 mL 1.1294 mL 2.2587 mL 5.6468 mL
30 mM 0.1882 mL 0.9411 mL 1.8823 mL 4.7057 mL
40 mM 0.1412 mL 0.7059 mL 1.4117 mL 3.5293 mL
50 mM 0.1129 mL 0.5647 mL 1.1294 mL 2.8234 mL
60 mM 0.0941 mL 0.4706 mL 0.9411 mL 2.3529 mL
80 mM 0.0706 mL 0.3529 mL 0.7059 mL 1.7646 mL
100 mM 0.0565 mL 0.2823 mL 0.5647 mL 1.4117 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Orotic acid-13C,15N2 monohydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orotic acid-13C,15N21346602-15-06-Carboxyuracil-13C,15N2Vitamin B13-13C,15N2Nucleoside Antimetabolite/AnalogEndogenous MetaboliteInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
Orotic acid-13C,15N2 monohydrate
Cat. No.:
HY-N0157S1
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.