2. Apoptosis
  3. TNF Receptor
  4. Ozoralizumab

Ozoralizumab  (Synonyms: ATN-103; PF-5230896)

Cat. No.: HY-P99796 Pureté: 99.80%
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Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. Ozoralizumab is a humanized trivalent nanobody compound that consists of two anti-human TNFα nanobodies and an anti-human serum albumin (HSA) nanobody. Ozoralizumab can be used in research of arthritis.

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CAS No. : 1167985-17-2

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Ozoralizumab Related Antibodies

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. Ozoralizumab is a humanized trivalent nanobody compound that consists of two anti-human TNFα nanobodies and an anti-human serum albumin (HSA) nanobody. Ozoralizumab can be used in research of arthritis[1].

Isotype

VH-VH'-VH, trivalent
Species Reactivity

Human
IC50 & Target

TNFα & ALB
In Vitro

Ozoralizumab (ATN-103; 0-1000 pM; 48 h) has high TNFα-neutralizing potency in the L929 cell cytotoxicity assay with KD values of 20.2 pM and 16.1 pM for human TNFα and monkey TNFα, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ozoralizumab Related Antibodies
In Vivo

Ozoralizumab (ATN-103; 1 mg/kg; s.c.; Tg197 human TNF transgenic mice) inhibits arthritis and reduces arthritis scores[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg197 human TNF transgenic mice[1]
Dosage: 1 mg/kg
Administration: Subcutaneous injection
Result: Reduced the mean histopathologic score in the Tg197 mice.
Had ability to neutralize TNFα activity.
Essai clinique
Gene ID

7124  [NCBI] & 213  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Masse moléculaire

38.43 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ozoralizumab]
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • VH-VH'-VH, trivalent
Biological Activity
  • Immobilized Human TNF-alpha Protein (hFc Tag) can bind Ozoralizumab. The EC50 for this effect is 62.82 ng/mL.
Pureté et documentation
Références
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Ozoralizumab Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ozoralizumab1167985-17-2ATN-103 PF-5230896ATN103ATN 103PF5230896PF 5230896PF-5230896TNF ReceptorTumor Necrosis Factor ReceptorTNFRserum albuminL929 cellarthritisInhibitorinhibitorinhibit

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