2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Petosemtamab

Petosemtamab  (Synonyms: MCLA 158)

製品番号: HY-P99406 純度: 99.94%
COA Technical Support

Petosemtamab (MCLA 158) is an anti- EGFR (Kd: 0.22 nM) and anti-LGR5 (Kd: 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 2213450-26-9

容量 価格（税別） 在庫状況 数量
>無料サンプル (100 μg)   今すぐ申し込む  
1 mg $430 在庫あり
5 mg $1120 在庫あり
10 mg $1800 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Petosemtamab Featured Recommendations:

Petosemtamab 関連抗体

Top Publications Citing Use of Products

EGFR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Petosemtamab (MCLA 158) is an anti- EGFR (Kd: 0.22 nM) and anti-LGR5 (Kd: 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC)[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target[2]

EGFR

0.22 nM (Kd)

LGR5

0.85 nM (Kd)

体外実験

Petosemtamab (MCLA 158) (1 µg/mL, 24 or 72 h) leads to EGFR degradation in EGFR+/LGR5+ colorectal cancer organoids[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Petosemtamab 関連抗体

Western Blot Analysis[2]

Cell Line: P18T (KRAS WT), C55T (KRAS G12V) and C82N (normal) organoids
Concentration: 1 µg/mL
Incubation Time: 1, 6, 24, 72 h
Result: Time-dependently degraded EGFR.
体内実験

Petosemtamab (MCLA 158) (25 mg/kg/week, i.v., for 6 weeks) leads to tumor regression in esophageal squamous, gastric adenocarcinoma and head & neck PDX models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Esophageal squamous, gastric adenocarcinoma and head & neck PDX models[2]
Dosage: 25 mg/kg/week
Administration: Intravenous injection (i.v.) for 6 weeks.
Result: Inhibited tumor growth.
臨床実験
Gene ID

8549  [NCBI] & 8549  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.5 kDa

CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Petosemtamab]
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized EGFR Protein, Human (621a.a, CHO, His, HY-P7340) can bind Petosemtamab. The EC50 for this effect is 4.45 ng/mL.
  • Immobilized HY-P79308 Lgr5/GPR49 Protein, Human (CHO, hFc) can bind Petosemtamab. The EC50 for this effect is 85 ng/mL.
純度とドキュメンテーション

純度: 99.94%

COA (232 KB) SDS-PAGE (453 KB) SEC-HPLC (399 KB)

Inhibitory Antibodies User Guide (603 KB)
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Petosemtamab Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Petosemtamab2213450-26-9MCLA 158MCLA158MCLA-158EGFREpidermal growth factor receptorErbB-1HER1CRCcolorectal cancerHNSCChead and neck squamous cell carcinomaEGFR degradationInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Petosemtamab
製品番号:
HY-P99406
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.