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  4. Pexiganan

Pexiganan  (Synonyms: MSI 78 free base)

製品番号: HY-105088 純度: 99.31%
COA 取扱説明書 Technical Support

Pexiganan (MSI 78) is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection.

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Pexiganan

Pexiganan 構造式

CAS 番号 : 147664-63-9

容量 価格（税別） 在庫状況 数量
5 mg $109 在庫あり
10 mg $185 在庫あり
25 mg $390 在庫あり
50 mg $630 在庫あり
100 mg $990 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Pexiganan 関連抗体

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製品説明

Pexiganan (MSI 78) is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection[1][2][3][4].

体外実験

Pexiganan (1-256 µg/mL; 24 h) exhibits comparable bactericidal activity against planktonic Staphylococcus aureus Z25.2, Pseudomonas aeruginosa Z25.1, and their dual-species cultures[1].
Pexiganan (1-256 µg/mL; 24 h) is more effective at inhibiting and eradicating Staphylococcus aureus Z25.2 biofilms than Pseudomonas aeruginosa Z25.1 or dual-species biofilms[1].
Pexiganan (7-35 μM) binds to purified bovine type I collagen with a dissociation constant of 34.01 μM[3].
Pexiganan (5-80 μg/mL; overnight) inhibits the growth of Pseudomonas aeruginosa and Staphylococcus aureus[3].
Pexiganan (40 μg/mL; 0-60 min) rapidly reduces viable counts of Pseudomonas aeruginosa (ATCC27853) and Staphylococcus aureus (ATCC29213) over 60 min, with complete elimination of P. aeruginosa by 60 min[3].
Pexiganan (10-50 μg/mL) exhibits no cytotoxicity toward rat fibroblast cells in in vitro MTT assays[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pexiganan 関連抗体
体内実験

Pexiganan (1 mg/kg; i.p.; single dose) reduces TNF-α leves in E. coli O111:B4 LPS (HY-D1056A1)-induced septic shock mice[4].
Pexiganan (1 mg/kg; i.p.; single dose) reduces lethality, and intra-abdominal bacterial counts in E. coli-induced septic shock in male Wistar rats[4].
Pexiganan (1 mg/kg; i.p.; single dose) reduces lethality, and intra-abdominal bacterial counts in in cecal ligation and puncture-induced septic shock in male Wistar rats[4].
Pexiganan (1 mg/kg; i.p.; single dose) is well-tolerated with no detectable adverse effects or physiological changes in healthy male Wistar rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (adult male, 200-300 g, E. coli O111:B4 LPS (HY-D1056A1)-induced septic shock)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Reduced plasma endotoxin levels to ≤0.015 EU/mL.
Reduced plasma TNF-α levels to 0.26 ng/mL.
Animal Model: Wistar rats (adult male, 200-300 g, E. coli-induced septic shock)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Resulted in 32.3% lethality, 5/15 positive blood cultures, and intra-abdominal bacterial counts of 6.0 × 103 CFU/mL.
Animal Model: Wistar rats (adult male, 200-300 g, cecal ligation and puncture-induced septic shock)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: When administered immediately after surgery, resulted in 32.3% lethality, 5/15 positive blood cultures, and intra-abdominal bacterial counts of 6.9 × 103 CFU/mL.
When administered immediately after surgery, produced significant reductions in plasma endotoxin and TNF-α levels compared to control and β-lactam-treated groups.
When administered 360 minutes after surgery, resulted in 40.0% lethality, 6/15 positive blood cultures, and intra-abdominal bacterial counts of 6.0 × 104 CFU/mL.
When administered 360 minutes after surgery, produced significant reductions in plasma endotoxin and TNF-α levels compared to control and β-lactam-treated groups.
Animal Model: Wistar rats (adult male, 200-300 g)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Showed no drug-related adverse effects.
Caused no changes in measured physiological parameters including leukocyte count, serum creatinine, rectal temperature, pulse, blood pressure, breathing rate, and oxygenation.
臨床実験
分子量

2477.17

分子式

C122H210N32O22
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence Shortening

GIGKFLKKAKKFGKAFVKILKK-NH2
Structure Classification
Initial Source

the skin of the African clawed frog
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (40.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (40.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4037 mL 2.0184 mL 4.0369 mL
5 mM 0.0807 mL 0.4037 mL 0.8074 mL
10 mM 0.0404 mL 0.2018 mL 0.4037 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.78%

COA (252 KB) RP-HPLC (196 KB) MS (71 KB) Elemental Analysis Report (110 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.4037 mL 2.0184 mL 4.0369 mL 10.0922 mL
5 mM 0.0807 mL 0.4037 mL 0.8074 mL 2.0184 mL
10 mM 0.0404 mL 0.2018 mL 0.4037 mL 1.0092 mL
15 mM 0.0269 mL 0.1346 mL 0.2691 mL 0.6728 mL
20 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5046 mL
25 mM 0.0161 mL 0.0807 mL 0.1615 mL 0.4037 mL
30 mM 0.0135 mL 0.0673 mL 0.1346 mL 0.3364 mL
40 mM 0.0101 mL 0.0505 mL 0.1009 mL 0.2523 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pexiganan Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pexiganan147664-63-9MSI 78MSI78MSI-78BacterialStaphylococcus aureus Z25.2peptidoglycanHelicobacter pyloriStaphylococcus aureus (ATCC29213)Pseudomonas aeruginosa (ATCC27853)rat fibroblast cellsseptic shockdiabetic foot infectionsPseudomonas aeruginosa Z25.1male Wistar ratsInhibitorinhibitorinhibit

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