2. Anti-infection
  3. Bacterial
  4. Pexiganan TFA

Pexiganan (MSI 78) TFA is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection.

For research use only. We do not sell to patients.

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Pexiganan TFA

Pexiganan TFA Chemical Structure

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Pexiganan TFA Related Antibodies

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Description

Pexiganan (MSI 78) TFA is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection[1][2][3][4].

In Vitro

Pexiganan (1-256 µg/mL; 24 h) TFA exhibits comparable bactericidal activity against planktonic Staphylococcus aureus Z25.2, Pseudomonas aeruginosa Z25.1, and their dual-species cultures[1].
Pexiganan (1-256 µg/mL; 24 h) TFA is more effective at inhibiting and eradicating Staphylococcus aureus Z25.2 biofilms than Pseudomonas aeruginosa Z25.1 or dual-species biofilms[1].
Pexiganan (7-35 μM) TFA binds to purified bovine type I collagen with a dissociation constant of 34.01 μM[3].
Pexiganan (5-80 μg/mL; overnight) TFA inhibits the growth of Pseudomonas aeruginosa and Staphylococcus aureus[3].
Pexiganan (40 μg/mL; 0-60 min) TFA rapidly reduces viable counts of Pseudomonas aeruginosa (ATCC27853) and Staphylococcus aureus (ATCC29213) over 60 min, with complete elimination of P. aeruginosa by 60 min[3].
Pexiganan (10-50 μg/mL) TFA exhibits no cytotoxicity toward rat fibroblast cells in in vitro MTT assays[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pexiganan TFA Related Antibodies
In Vivo

Pexiganan (1 mg/kg; i.p.; single dose) TFA reduces TNF-α leves in E. coli O111:B4 LPS (HY-D1056A1)-induced septic shock mice[4].
Pexiganan (1 mg/kg; i.p.; single dose) TFA reduces lethality, and intra-abdominal bacterial counts in E. coli-induced septic shock in male Wistar rats[4].
Pexiganan (1 mg/kg; i.p.; single dose) TFA reduces lethality, and intra-abdominal bacterial counts in in cecal ligation and puncture-induced septic shock in male Wistar rats[4].
Pexiganan (1 mg/kg; i.p.; single dose) TFA is well-tolerated with no detectable adverse effects or physiological changes in healthy male Wistar rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (adult male, 200-300 g, E. coli O111:B4 LPS (HY-D1056A1)-induced septic shock)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Reduced plasma endotoxin levels to ≤0.015 EU/mL.
Reduced plasma TNF-α levels to 0.26 ng/mL.
Animal Model: Wistar rats (adult male, 200-300 g, E. coli-induced septic shock)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Resulted in 32.3% lethality, 5/15 positive blood cultures, and intra-abdominal bacterial counts of 6.0 × 103 CFU/mL.
Animal Model: Wistar rats (adult male, 200-300 g, cecal ligation and puncture-induced septic shock)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: When administered immediately after surgery, resulted in 32.3% lethality, 5/15 positive blood cultures, and intra-abdominal bacterial counts of 6.9 × 103 CFU/mL.
When administered immediately after surgery, produced significant reductions in plasma endotoxin and TNF-α levels compared to control and β-lactam-treated groups.
When administered 360 minutes after surgery, resulted in 40.0% lethality, 6/15 positive blood cultures, and intra-abdominal bacterial counts of 6.0 × 104 CFU/mL.
When administered 360 minutes after surgery, produced significant reductions in plasma endotoxin and TNF-α levels compared to control and β-lactam-treated groups.
Animal Model: Wistar rats (adult male, 200-300 g)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Showed no drug-related adverse effects.
Caused no changes in measured physiological parameters including leukocyte count, serum creatinine, rectal temperature, pulse, blood pressure, breathing rate, and oxygenation.
Molecular Weight

2477.17 (free base)

Formula

C122H210N32O22·xC2H4O2
Sequence

Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2
Sequence Shortening

GIGKFLKKAKKFGKAFVKILKK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pexiganan TFA Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PexigananMSI 78MSI78MSI-78BacterialStaphylococcus aureus Z25.2peptidoglycanHelicobacter pyloriStaphylococcus aureus (ATCC29213)Pseudomonas aeruginosa (ATCC27853)rat fibroblast cellsseptic shockdiabetic foot infectionsPseudomonas aeruginosa Z25.1male Wistar ratsInhibitorinhibitorinhibit

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