Pexiganan acetate
Based on 1 Customer Validation
Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection.
For research use only. We do not sell to patients.
- Purity: 99.31%
- CAS No.: 172820-23-4
- Formula: C122H210N32O22.xC2H4O2
- Molecular Weight:2477.17 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Pexiganan (1-256 µg/mL; 24 h) acetate exhibits comparable bactericidal activity against planktonic Staphylococcus aureus Z25.2, Pseudomonas aeruginosa Z25.1, and their dual-species cultures[1].
Pexiganan (1-256 µg/mL; 24 h) acetate is more effective at inhibiting and eradicating Staphylococcus aureus Z25.2 biofilms than Pseudomonas aeruginosa Z25.1 or dual-species biofilms[1].
Pexiganan (7-35 μM) acetate binds to purified bovine type I collagen with a dissociation constant of 34.01 μM[3].
Pexiganan (5-80 μg/mL; overnight) acetate inhibits the growth of Pseudomonas aeruginosa and Staphylococcus aureus[3].
Pexiganan (40 μg/mL; 0-60 min) acetate rapidly reduces viable counts of Pseudomonas aeruginosa (ATCC27853) and Staphylococcus aureus (ATCC29213) over 60 min, with complete elimination of P. aeruginosa by 60 min[3].
Pexiganan (10-50 μg/mL) acetate exhibits no cytotoxicity toward rat fibroblast cells in in vitro MTT assays[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces lethality, and intra-abdominal bacterial counts in E. coli-induced septic shock in male Wistar rats[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces lethality, and intra-abdominal bacterial counts in in cecal ligation and puncture-induced septic shock in male Wistar rats[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate is well-tolerated with no detectable adverse effects or physiological changes in healthy male Wistar rats[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (adult male, 200-300 g, E. coli O111:B4 LPS (HY-D1056A1)-induced septic shock)[4]
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Dosage:1 mg/kg
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Administration:i.p.; single dose
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Result:Reduced plasma endotoxin levels to ≤0.015 EU/mL.
Reduced plasma TNF-α levels to 0.26 ng/mL.
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Animal Model:Wistar rats (adult male, 200-300 g, E. coli-induced septic shock)[4]
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Dosage:1 mg/kg
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Administration:i.p.; single dose
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Result:Resulted in 32.3% lethality, 5/15 positive blood cultures, and intra-abdominal bacterial counts of 6.0 × 103 CFU/mL.
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Animal Model:Wistar rats (adult male, 200-300 g, cecal ligation and puncture-induced septic shock)[4]
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Dosage:1 mg/kg
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Administration:i.p.; single dose
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Result:When administered immediately after surgery, resulted in 32.3% lethality, 5/15 positive blood cultures, and intra-abdominal bacterial counts of 6.9 × 103 CFU/mL.
When administered immediately after surgery, produced significant reductions in plasma endotoxin and TNF-α levels compared to control and β-lactam-treated groups.
When administered 360 minutes after surgery, resulted in 40.0% lethality, 6/15 positive blood cultures, and intra-abdominal bacterial counts of 6.0 × 104 CFU/mL.
When administered 360 minutes after surgery, produced significant reductions in plasma endotoxin and TNF-α levels compared to control and β-lactam-treated groups.
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Animal Model:Wistar rats (adult male, 200-300 g)[4]
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Dosage:1 mg/kg
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Administration:i.p.; single dose
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Result:Showed no drug-related adverse effects.
Caused no changes in measured physiological parameters including leukocyte count, serum creatinine, rectal temperature, pulse, blood pressure, breathing rate, and oxygenation.
Chemical Information
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CAS No. 172820-23-4
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Appearance Solid
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Molecular Weight 2477.17 (free base)
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Formula C122H210N32O22.xC2H4O2
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Color White to off-white
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Synonyms
MSI 78
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Sequence
Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2
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Sequence Shortening
GIGKFLKKAKKFGKAFVKILKK-NH2
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Structure Classification
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Initial Source
the skin of the African clawed frog
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Gomes D, et al. Pexiganan in Combination with Nisin to Control Polymicrobial Diabetic Foot Infections. Antibiotics (Basel). 2020;9(3):128. Published 2020 Mar 20. [Content Brief]
[2]. Ghazvini K, et al. Sustain-release lipid-liquid crystal formulations of pexiganan against Helicobacter pylori infection: in vitro evaluation in C57BL/6 mice. BMC Pharmacol Toxicol. 2024;25(1):9. Published 2024 Jan 11. [Content Brief]
[3]. Gopinath D, et al. Pexiganan-incorporated collagen matrices for infected wound-healing processes in rat. J Biomed Mater Res A. 2005;73(3):320-331. [Content Brief]
[4]. Giacometti A, et al. Effects of pexiganan alone and combined with betalactams in experimental endotoxic shock. Peptides. 2005;26(2):207-216. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pexiganan acetate Related Classifications
HY-105088A Related Classifications
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