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Art. -Nr.: HY-105088A

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Pexiganan acetate

(Synonyms: MSI 78)

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Based on 1 Customer Validation

Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.31%
CAS. Nr.: 172820-23-4
Formel: C₁₂₂H₂₁₀N₃₂O₂₂.xC₂H₄O₂
Molecular Weight:2477.17 (free base)

Speicherung:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pexiganan acetate Chemical Structure

CAS. Nr.: 172820-23-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Pexiganan (1-256 µg/mL; 24 h) acetate exhibits comparable bactericidal activity against planktonic Staphylococcus aureus Z25.2, Pseudomonas aeruginosa Z25.1, and their dual-species cultures^[1].
Pexiganan (1-256 µg/mL; 24 h) acetate is more effective at inhibiting and eradicating Staphylococcus aureus Z25.2 biofilms than Pseudomonas aeruginosa Z25.1 or dual-species biofilms^[1].
Pexiganan (7-35 μM) acetate binds to purified bovine type I collagen with a dissociation constant of 34.01 μM^[3].
Pexiganan (5-80 μg/mL; overnight) acetate inhibits the growth of Pseudomonas aeruginosa and Staphylococcus aureus^[3].
Pexiganan (40 μg/mL; 0-60 min) acetate rapidly reduces viable counts of Pseudomonas aeruginosa (ATCC27853) and Staphylococcus aureus (ATCC29213) over 60 min, with complete elimination of P. aeruginosa by 60 min^[3].
Pexiganan (10-50 μg/mL) acetate exhibits no cytotoxicity toward rat fibroblast cells in in vitro MTT assays^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces TNF-α leves in E. coli O111:B4 LPS (HY-D1056A1)-induced septic shock mice^[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces lethality, and intra-abdominal bacterial counts in E. coli-induced septic shock in male Wistar rats^[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces lethality, and intra-abdominal bacterial counts in in cecal ligation and puncture-induced septic shock in male Wistar rats^[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate is well-tolerated with no detectable adverse effects or physiological changes in healthy male Wistar rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (adult male, 200-300 g, E. coli O111:B4 LPS (HY-D1056A1)-induced septic shock)^[4]
Dosage:

1 mg/kg
Administration:

i.p.; single dose
Result:

Reduced plasma endotoxin levels to ≤0.015 EU/mL.
Reduced plasma TNF-α levels to 0.26 ng/mL.

Animal Model:

Wistar rats (adult male, 200-300 g, E. coli-induced septic shock)^[4]
Dosage:

1 mg/kg
Administration:

i.p.; single dose
Result:

Resulted in 32.3% lethality, 5/15 positive blood cultures, and intra-abdominal bacterial counts of 6.0 × 10³ CFU/mL.

Animal Model:

Wistar rats (adult male, 200-300 g, cecal ligation and puncture-induced septic shock)^[4]
Dosage:

1 mg/kg
Administration:

i.p.; single dose
Result:

When administered immediately after surgery, resulted in 32.3% lethality, 5/15 positive blood cultures, and intra-abdominal bacterial counts of 6.9 × 10³ CFU/mL.
When administered immediately after surgery, produced significant reductions in plasma endotoxin and TNF-α levels compared to control and β-lactam-treated groups.
When administered 360 minutes after surgery, resulted in 40.0% lethality, 6/15 positive blood cultures, and intra-abdominal bacterial counts of 6.0 × 10⁴ CFU/mL.
When administered 360 minutes after surgery, produced significant reductions in plasma endotoxin and TNF-α levels compared to control and β-lactam-treated groups.

Animal Model:

Wistar rats (adult male, 200-300 g)^[4]
Dosage:

1 mg/kg
Administration:

i.p.; single dose
Result:

Showed no drug-related adverse effects.
Caused no changes in measured physiological parameters including leukocyte count, serum creatinine, rectal temperature, pulse, blood pressure, breathing rate, and oxygenation.

Chemical Information

CAS. Nr. 172820-23-4
Appearance Solid
Molecular Weight 2477.17 (free base)
Formel C₁₂₂H₂₁₀N₃₂O₂₂.xC₂H₄O₂
Color White to off-white
Synonyms

MSI 78
Sequence

Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2
Sequence Shortening

GIGKFLKKAKKFGKAFVKILKK-NH2
Structure Classification
- Others
Initial Source
- Animals
the skin of the African clawed frog
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gomes D, et al. Pexiganan in Combination with Nisin to Control Polymicrobial Diabetic Foot Infections. Antibiotics (Basel). 2020;9(3):128. Published 2020 Mar 20. [Content Brief]

[2]. Ghazvini K, et al. Sustain-release lipid-liquid crystal formulations of pexiganan against Helicobacter pylori infection: in vitro evaluation in C57BL/6 mice. BMC Pharmacol Toxicol. 2024;25(1):9. Published 2024 Jan 11. [Content Brief]

[3]. Gopinath D, et al. Pexiganan-incorporated collagen matrices for infected wound-healing processes in rat. J Biomed Mater Res A. 2005;73(3):320-331. [Content Brief]

[4]. Giacometti A, et al. Effects of pexiganan alone and combined with betalactams in experimental endotoxic shock. Peptides. 2005;26(2):207-216. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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