2. Anti-infection
  3. Bacterial
  4. Pexiganan acetate

Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection.

For research use only. We do not sell to patients.

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Pexiganan acetate

Pexiganan acetate Chemical Structure

CAS No. : 172820-23-4

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Based on 1 publication(s) in Google Scholar

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Pexiganan acetate Related Antibodies

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Description

Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection[1][2][3][4].

In Vitro

Pexiganan (1-256 µg/mL; 24 h) acetate exhibits comparable bactericidal activity against planktonic Staphylococcus aureus Z25.2, Pseudomonas aeruginosa Z25.1, and their dual-species cultures[1].
Pexiganan (1-256 µg/mL; 24 h) acetate is more effective at inhibiting and eradicating Staphylococcus aureus Z25.2 biofilms than Pseudomonas aeruginosa Z25.1 or dual-species biofilms[1].
Pexiganan (7-35 μM) acetate binds to purified bovine type I collagen with a dissociation constant of 34.01 μM[3].
Pexiganan (5-80 μg/mL; overnight) acetate inhibits the growth of Pseudomonas aeruginosa and Staphylococcus aureus[3].
Pexiganan (40 μg/mL; 0-60 min) acetate rapidly reduces viable counts of Pseudomonas aeruginosa (ATCC27853) and Staphylococcus aureus (ATCC29213) over 60 min, with complete elimination of P. aeruginosa by 60 min[3].
Pexiganan (10-50 μg/mL) acetate exhibits no cytotoxicity toward rat fibroblast cells in in vitro MTT assays[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pexiganan acetate Related Antibodies
In Vivo

Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces TNF-α leves in E. coli O111:B4 LPS (HY-D1056A1)-induced septic shock mice[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces lethality, and intra-abdominal bacterial counts in E. coli-induced septic shock in male Wistar rats[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces lethality, and intra-abdominal bacterial counts in in cecal ligation and puncture-induced septic shock in male Wistar rats[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate is well-tolerated with no detectable adverse effects or physiological changes in healthy male Wistar rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (adult male, 200-300 g, E. coli O111:B4 LPS (HY-D1056A1)-induced septic shock)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Reduced plasma endotoxin levels to ≤0.015 EU/mL.
Reduced plasma TNF-α levels to 0.26 ng/mL.
Animal Model: Wistar rats (adult male, 200-300 g, E. coli-induced septic shock)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Resulted in 32.3% lethality, 5/15 positive blood cultures, and intra-abdominal bacterial counts of 6.0 × 103 CFU/mL.
Animal Model: Wistar rats (adult male, 200-300 g, cecal ligation and puncture-induced septic shock)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: When administered immediately after surgery, resulted in 32.3% lethality, 5/15 positive blood cultures, and intra-abdominal bacterial counts of 6.9 × 103 CFU/mL.
When administered immediately after surgery, produced significant reductions in plasma endotoxin and TNF-α levels compared to control and β-lactam-treated groups.
When administered 360 minutes after surgery, resulted in 40.0% lethality, 6/15 positive blood cultures, and intra-abdominal bacterial counts of 6.0 × 104 CFU/mL.
When administered 360 minutes after surgery, produced significant reductions in plasma endotoxin and TNF-α levels compared to control and β-lactam-treated groups.
Animal Model: Wistar rats (adult male, 200-300 g)[4]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Showed no drug-related adverse effects.
Caused no changes in measured physiological parameters including leukocyte count, serum creatinine, rectal temperature, pulse, blood pressure, breathing rate, and oxygenation.
Molecular Weight

2477.17 (free base)

Formula

C122H210N32O22.xC2H4O2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2
Sequence Shortening

GIGKFLKKAKKFGKAFVKILKK-NH2
Structure Classification
Initial Source

the skin of the African clawed frog
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Pexiganan acetate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pexiganan172820-23-4MSI 78MSI78MSI-78BacterialStaphylococcus aureus Z25.2peptidoglycanHelicobacter pyloriStaphylococcus aureus (ATCC29213)Pseudomonas aeruginosa (ATCC27853)rat fibroblast cellsseptic shockdiabetic foot infectionsPseudomonas aeruginosa Z25.1male Wistar ratsInhibitorinhibitorinhibit

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