2. Immunology/Inflammation Antibody-drug Conjugate/ADC Related
  3. Interleukin Related ADC Antibody
  4. Pivekimab

Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN).

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CAS. Nr. : 2234335-84-1

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Pivekimab Related Antibodies

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Beschreibung

Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN)[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

IL-3Ra/CD123
In Vitro

Pivekimab can be utilized in the synthesis of pivekimab sunirine, a CD123-targeting antibody-drug conjugate (ADC) comprising Pivekimab, cleavable linker, and an indolinobenzodiazepine pseudodimer payload[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pivekimab Related Antibodies
Klinische Studie
Gene ID

3563  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molekulargewicht

145.98 kDa

CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Pivekimab]
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human IL-3R alpha/CD123 Protein (ECD, His Tag) can bind Pivekimab. The EC50 for this effect is 6.14 ng/mL.
  • Flow cytometric analysis of 1.5X106 THP-1 cells with Pivekimab (HY-P99234, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Reinheit & Dokumentation

Purity: 97.19%

SDS (251 KB)

COA (232 KB) SDS-PAGE (87 KB) SEC-HPLC (226 KB)

Inhibitory Antibodies User Guide (603 KB)
Verweise
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Pivekimab Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pivekimab2234335-84-1Interleukin RelatedADC AntibodyILIgG1 antibodyhumanized monoclonal antibodyCD123BPDCNInhibitorinhibitorinhibit

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Produktname:
Pivekimab
Art. -Nr.:
HY-P99234
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SAFETY DATA SHEET (SDS)

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