IL3RA - interleukin 3 receptor subunit alpha Gene

Also Known as IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 3563

About IL3RA

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,336,785-1,382,689 (from NCBI)

This gene has 3 transcripts (splice variants), 593 orthologues and 23 paralogues. Ubiquitous expression in lung (RPKM 8.7), lymph node (RPKM 8.6) and 24 other tissues.

Summary

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

IL3RA Products (2)

mRNA Protein Name
NM_001267713.2 NP_001254642.1 interleukin-3 receptor subunit alpha isoform 2 precursor
NM_002183.4 NP_002174.1 interleukin-3 receptor subunit alpha isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables interleukin-3 receptor activity IDA
IDA: Inferred from direct assay
29374162 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29374162 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in interleukin-3-mediated signaling pathway IDA
IDA: Inferred from direct assay
8649415 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL3RA Protein Structure

IL6Ra-bind

IL6Ra-bind: Interleukin-6 receptor alpha chain, binding (107 - 204)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
Protein Preferred Names Protein Names

interleukin-3 receptor subunit alpha

  • CD123 antigen

IL3RA Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
IL3RA P26951 SMAGP Homo sapiens Q0VAQ4
Validated Y2H
32296183
Intra
IL3RA P26951 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
IL3RA P26951 PAQR5 Homo sapiens Q9NXK6
Validated Y2H
32296183
Intra
IL3RA P26951 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
IL3RA P26951 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra
IL3RA P26951 TMEM128 Homo sapiens Q5BJH2-2
Validated Y2H
32296183
Intra
IL3RA P26951 TMEM254 Homo sapiens Q8TBM7
Validated Y2H
32296183
Intra
IL3RA P26951 TUSC5 Homo sapiens A5PKU2
Validated Y2H
32296183
Intra
IL3RA P26951 GIMAP1 Homo sapiens Q8WWP7
Validated Y2H
32296183
Intra
IL3RA P26951 CLDN19 Homo sapiens Q8N6F1-2
Validated Y2H
32296183
Intra
IL3RA P26951 SYS1 Homo sapiens Q8N2H4
Validated Y2H
32296183
Intra
IL3RA P26951 EMP3 Homo sapiens P54852
Validated Y2H
32296183
Intra
IL3RA P26951 TMEM65 Homo sapiens Q6PI78
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL3RA Proteins

製品番号 製品名 アクセッション番号 純度
HY-P70468 IL-3R alpha/CD123 Protein, Human (HEK293, His) P26951-1 (T19-R305) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72349 IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, Fc-Avi) P26951-1 (T19-R305) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700747 IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, His-Avi) P26951-1 (T19-R305) ≥ 95%, as determined by reducing SDS-PAGE.

IL3RA 抗体

製品番号 製品名 アプリケーション 反応性
HY-P811037 CD123 Antibody WB, ICC/IF Human, Mouse, Rat
HY-P81713 CD123 Antibody (YA1458) FC, ELISA Human

関連疾患

Diseases Alias
Diphtheria

  • Corynebacterium Infections

  • Corynebacterium Infection

  • Diphtherial Infection

  • Infection Due To Corynebacterium Diphtheriae
Hairy Cell Leukemia

  • Hcl-V

  • Hairy Cell Leukemia Variant

  • Hairy Cell Leukaemia Variant

  • Hcl

  • Leukemic Reticuloendotheliosis

  • Leukemic Reticuloendotheliosis Variant

  • Prolymphocytic Variant Of Hcl

  • Prolymphocytic Variant Of Hairy Cell Leukemia

  • Leukemia Hairy Cell

  • Leukemia, Hairy Cell

  • Leukaemic Reticuloendotheliosis

  • Lre - [Leukemic Reticuloendotheliosis]

  • Hairy-Cell Leukaemia, Nos

  • Hcl - [Hairy Cell Leukaemia]

  • Hairy-Cell Leukaemia Without Mention Of Remission
Acute Leukemia

  • Stem Cell Leukaemia

  • Stem Cell Leukemia

  • Acute Leukemias

  • Acute Undifferentiated Leukemia

  • Undifferentiated Leukemia

  • Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission

  • Blast Cell Leukaemia

  • Blast Leukaemia

  • Blastic Leukaemia

  • Undifferentiated Leukaemia
Chronic Urticaria

  • Urticaria Chronic

  • Chronic Spontaneous Urticaria

  • Chronic Ordinary Urticaria
Pulmonary Alveolar Proteinosis
Mastocytosis

  • Mast Cell Disease

  • Mast Cell Hyperplasia

  • Urticaria Pigmentosa

  • Malignant Mastocytoma

  • Malignant Mast Cell Tumours

  • Malignant Mastocytosis
Acute Basophilic Leukemia
Keratoacanthoma

  • Ka - [Keratoacanthoma]

  • Well-Differentiated Squamous Cell Carcinoma
Hematologic Cancer

  • Hematologic Neoplasm

  • Hematologic Neoplasms

  • Hematologic Malignancies

  • Blood Cancer

  • Hematologic Malignancy

  • Hematological Tumors

  • Hematopoietic And Lymphoid System Tumor

  • Hematopoietic Cancer

  • Hematopoietic Neoplasm

  • Hematopoietic Tumors

  • Malignant Hematopoietic Neoplasm

  • Liquid Tumor

  • Hematopoietic Neoplasms
Refractory Hairy Cell Leukemia
Amoxicillin Allergy
Oxirane Allergy

  • Ethylene Oxide Allergy

  • Eto Allergy
Capillary Disease

  • Disease Of Capillaries
Refractory Hematologic Cancer

  • Refractory Hematologic Malignancy
Capillary Leak Syndrome

  • Systemic Capillary Leak Syndrome

  • Clarkson Disease

  • Capillary Leak Syndrome With Monoclonal Gammopathy

  • Scls

  • Periodic Systemic Capillary Leak Syndrome

  • Capillary Hyperpermeability Syndrome

  • Idiopathic Capillary Leak Syndrome
Spleen Cancer

  • Spleen Neoplasm

  • Splenic Neoplasm

  • Splenic Neoplasms

  • Malignant Splenic Tumor

  • Malignant Tumour Of Spleen

  • Tumor Of Spleen

  • Malignant Neoplasm Of Spleen
Splenic Marginal Zone Lymphoma

  • Smzl

  • Splenic Marginal Zone B-Cell Lymphoma
Cutaneous Lupus Erythematosus

  • Lupus Erythematosus, Cutaneous

  • Lupus Erythematosus Cutaneous
Diclofenac Allergy

  • Voltaren Allergy
Lymphoma, Hodgkin, Classic

  • Hodgkin Lymphoma

  • Hodgkin Disease

  • Hodgkin'S Lymphoma

  • Hodgkins Lymphoma

  • Classic Hodgkin Lymphoma

  • CHL

  • Hodgkin Lymphoma, Susceptibility To

  • Hl

  • Hodgkin'S Sarcoma

  • Stage I Subdiaphragmatic Hodgkin Lymphoma

  • Stage Ii Subdiaphragmatic Hodgkin Lymphoma

  • Lymphoma, Hodgkin'S

  • Classic Hodgkin Disease

  • Hodgkin'S Disease

  • Lymphoma, Hodgkin, Susceptibility To

  • Hodgkin'S Disease Of Intrapelvic Lymph Nodes

  • Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

  • Malignant Lymphogranuloma

  • Malignant Lymphogranulomatosis

  • Malignant Hodgkin Lymphoma

  • Classical Hodgkin Lymphoma, Type Not Specified
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Chlorhexidine Allergy
Chronic Myelomonocytic Leukemia

  • Leukemia, Myelomonocytic, Chronic

  • Cmml

  • Leukemia Myelomonocytic Chronic

  • Cmml - [Chronic Myelomonocytic Leukaemia]

  • Chronic Myelomonocytic Leukaemia Without Mention Of Remission

  • Chronic Monocytic Leukaemia

  • Chronic Monocytoid Leukaemia
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Pancytopenia
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Myelodysplastic Syndrome

  • Myelodysplastic Syndromes

  • Myelodysplasia

  • MDS

  • Myelodysplastic Syndrome Included

  • Myelodysplastic Syndrome, Susceptibility To, Included

  • Myelodysplastic Syndrome, Somatic

  • Myelodysplastic Syndrome, Susceptibility To
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

阻害性抗体 (1)
製品番号 製品名 製品効果
純度 Phase
HY-P991282 KHK2823 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS06764 IL3RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174605 Human IL3RA mRNA / Unkown
阻害性抗体 (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P991699 Lixarkitug Inhibitor 99% Unkown
HY-P990451 Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) Inhibitor 95.01% Unkown
HY-P992032 TPP-9476 Antagonist / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus IL3RA MGD MGI:96553
Canis familiaris IL3RA VGNC VGNC:54959
Rattus norvegicus IL3RA RGD RGD:628728
Bos taurus IL3RA VGNC VGNC:106780