CD123 Antibody
(Synonyms: CD123, IL3R, IL3RA, Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA)CD123 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CD123.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
CD123 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CD123.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 42 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 43 kDa
Synthetic peptide corresponding to the center region of human CD123.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD123 is a Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity)[1].
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Subcellular Localization
Cell membrane
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Isoforms & Post-Translational Modification
CD123 has 2 isoforms, P26951-1: amino acid length is 378, molecular weight is 43330 Da (predicted); P26951-2: amino acid length is 300, molecular weight is 34466 Da (predicted).响应 IL3 刺激时可被 RNFT2 泛素化，该泛素化会导致配体诱导的蛋白酶体降解。可被 RNF128 通过“Lys-27”连接的多聚泛素化修饰，促进其通过溶酶体途径降解(PubMed:38702781)CD123 存在 2 个异构体，P26951-1：氨基酸个数为 378 个，分子量为 43330 Da (预测)；P26951-2：氨基酸个数为 300 个，分子量为 34466 Da (预测)。Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. Ubiquitinated by RNF128 via 'Lys-27'-linked polyubiquitination, facilitating its degradation through the lysosomal pathway (PubMed:38702781)
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Subunit
Interacts with IL3.
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SwissProt ID
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Synonyms
CD123, IL3R, IL3RA, Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA
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