2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Transmembrane Glycoprotein Topoisomerase
  4. Precemtabart tocentecan

Precemtabart tocentecan  (Synonyms: Precem-TcT; M 9140)

製品番号: HY-177434 純度: 99.31%
COA 取扱説明書 Technical Support

Precemtabart tocentecan (Precem-TcT; M 9140) is an anti-CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) antibody-drug conjugate (ADC). Precemtabart tocentecan consists of a tumor-specific anti-CEACAM5 monoclonal antibody Precemtabart (HY-P990940), a highly hydrophilic and stable cleavable β-glucuronide linker, and a topoisomerase 1 inhibitor payload Exatecan (HY-13631), and the drug-linker conjugate for ADC is Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179). Precemtabart tocentecan inhibits the growth of CEACAM5-positive cancer cells. Precemtabart tocentecan exhibits significant antitumor activity in CEACAM5-expressing xenograft models. Precemtabart tocentecan can be used for the study of CEACAM5-expressing advanced solid tumors, especially mCRC.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Precemtabart tocentecan

Precemtabart tocentecan 構造式

CAS 番号 : 2873366-83-5

容量 価格（税別） 在庫状況 数量
1 mg $485 在庫あり
5 mg $1220 在庫あり
10 mg $1950 在庫あり
25 mg $3600 在庫あり
50 mg $5760 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Precemtabart tocentecan 関連抗体

Top Publications Citing Use of Products

Topoisomerase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Topoisomerase Topo I Topo II DNA gyrase

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Precemtabart tocentecan (Precem-TcT; M 9140) is an anti-CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) antibody-drug conjugate (ADC). Precemtabart tocentecan consists of a tumor-specific anti-CEACAM5 monoclonal antibody Precemtabart (HY-P990940), a highly hydrophilic and stable cleavable β-glucuronide linker, and a topoisomerase 1 inhibitor payload Exatecan (HY-13631), and the drug-linker conjugate for ADC is Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179). Precemtabart tocentecan inhibits the growth of CEACAM5-positive cancer cells. Precemtabart tocentecan exhibits significant antitumor activity in CEACAM5-expressing xenograft models. Precemtabart tocentecan can be used for the study of CEACAM5-expressing advanced solid tumors, especially mCRC[1].

IC50 & Target[1]

Topoisomerase I

 

体外実験

Precemtabart tocentecan (0.09-0.63 nM, 144 h) potently inhibits the viability of CEACAM5-positive SK-CO-1 and MKN45 cells, with IC50 values of 0.09 nM and 0.63 nM respectively[1].
Precemtabart tocentecan (1 nM, 6 days) induces cell death in CEACAM5-negative MDA-MB-231 cells when co-cultured with CEACAM5-positive SK-CO-1 cells, and the effect is enhanced with increasing number of SK-CO-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Precemtabart tocentecan 関連抗体
体内実験

Precemtabart tocentecan (6 mg/kg, i.v., once on day 0) exerts potent antitumor activity, achieving tumor stasis in CEACAM5-high COPF230 or REPF210 cancer-derived xenograft model[1].
Precemtabart tocentecan (4 mg/kg, i.v., once every 2 weeks for 3 doses) exerts potent antitumor activity in Irinotecan (HY-16562A)-pretreated CXF4102 CRC PDX model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: COPF230 or REPF210 tumor fragments were subcutaneously implanted into the right flanks of 5-6-week-old female immunodeficient mice[1]
Dosage: 6 mg/kg
Administration: i.v., once on day 0
Result: Achieved tumor stasis (-29% tumor volume on day 52) in COPF230 model and tumor regression (-72% tumor volume on day 52) in REPF210 model.
Animal Model: CXF4102 tumor fragments were subcutaneously implanted into the right flanks of 6-8-week-old female immunodeficient mice[1]
Dosage: 4 mg/kg
Administration: i.v., once every 2 weeks for 3 doses
Result: Induced substantial tumor regression (-73% tumor volume on day 32) with sustained inhibition (-57% tumor volume on day 60) in irinotecan-pretreated CXF4102 model.
臨床実験
分子量

152832 (average)

CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Precemtabart tocentecan]
輸送条件

Shipping with dry ice.
保管条件

-80°C, protect from light
純度とドキュメンテーション

純度: 99.31%

COA (232 KB) Others (124 KB) SEC-HPLC (85 KB)

取扱説明書 (2659 KB)
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Precemtabart tocentecan Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Precemtabart tocentecan2873366-83-5Precem-TcT M 9140M9140M 9140M-9140Antibody-Drug Conjugates (ADCs)Transmembrane GlycoproteinTopoisomeraseAntibody-Drug Conjugatesantibody-drug conjugateCEACAM5topoisomerase 1cancersInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Precemtabart tocentecan
製品番号:
HY-177434
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.