PU-11
PU-11 is a Hsp90α/Hsp90β inhibitor with IC50 values of 18.6 μM and 89.8 μM and Kd values of 2 and 4.2 μM. PU-11 binds to the ATP-binding pocket of Hsp90α and Hsp90β and displays selective binding preference for Hsp90α over Hsp90β, mediated by the nonconserved Hsp90α Ser52 residue. PU-11 can be used for the research of neurodegenerative disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1454619-18-1
- 分子式: C19H23N5O3
- 分子量:369.43
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
|
HSP90α 18.6 μM (IC50) |
HSP90β 89.8 μM (IC50) |
HSP90α 2 μM (Kd) |
HSP90β 4.2 μM (Kd) |
体外実験
PU-11 (Compound PU-11-trans) (30.1-50.7 μM) binds to purified human Hsp90α NTD with a Kd of 2.0 ± 0.14 μM and an IC50 of 18.6 μM, exhibiting selective affinity for this paralog[1].
PU-11 (93.3-97.8 μM) binds to purified human Hsp90β NTD with a Kd of 4.2 ± 0.74 μM and an IC50 of 89.8 μM, showing lower affinity than for Hsp90α[1].
PU-11 (33.0-41.8 μM) binds to purified human Hsp90αS52A mutant NTD with a Kd of 4.2 ± 0.03 μM, matching its affinity for wild-type Hsp90β[1].
PU-11 shows IC50 values of 111.4 ± 9.7 and 172.9 ± 7.3 μM for Grp94 and Trap-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1454619-18-1
-
分子量 369.43
-
分子式 C19H23N5O3
-
SMILES
C(/C=C/C)N1C=2C(N=C1CC3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=CN2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PU-11 関連分類
HY-116053 関連分類
Powered by Bioz