1454619-18-1
Chemical Structure
PU-11
- CAS No.: 1454619-18-1
- Formula:C19H23N5O3
- Molecular Weight:369.43
IUPAC Name: (E)-9-(but-2-en-1-yl)-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine
InChIKey: ZAFMHPQRCYVTLV-AATRIKPKSA-N
SMILES: C(/C=C/C)N1C=2C(N=C1CC3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=CN2
Biological Activity: PU-11 is a Hsp90α/Hsp90β inhibitor with IC50 values of 18.6 μM and 89.8 μM and Kd values of 2 and 4.2 μM. PU-11 binds to the ATP-binding pocket of Hsp90α and Hsp90β and displays selective binding preference for Hsp90α over Hsp90β, mediated by the nonconserved Hsp90α Ser52 residue. PU-11 can be used for the research of neurodegenerative disorders[1].
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PU-11 | PU-11 is a Hsp90α/Hsp90β inhibitor with IC50 values of 18.6 μM and 89.8 μM and Kd values of 2 and 4.2 μM. PU-11 binds to the ATP-binding pocket of Hsp90α and Hsp90β and displays selective binding preference for Hsp90α over Hsp90β, mediated by the nonconserved Hsp90α Ser52 residue. PU-11 can be used for the research of neurodegenerative disorders. | |||||||||||||||||||||
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Keywords
