2. Anti-infection
  3. SARS-CoV HBV
  4. Punicalagin

プニカラギン  (Synonyms: Punicalagin)

製品番号: HY-N0063 純度: 99.89%
COA 取扱説明書 Technical Support

Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 65995-63-3

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 118 在庫あり
Solution
10 mM * 1 mL in DMSO USD 118 在庫あり
Solid
5 mg $55 在庫あり
10 mg $99 在庫あり
20 mg $165 在庫あり
50 mg $330 在庫あり
100 mg $528 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 15 publication(s) in Google Scholar

Other Forms of Punicalagin:

プニカラギン 関連抗体

Top Publications Citing Use of Products

    Punicalagin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Sep 3.  [Abstract]

    Body weight changes in Female BALB/c mice aged 6–8 weeks after treatment with 20 mg/kg of Salvianolic acid A (SAA), Chebulinic Acid, Tannic acid, or Punicalagin via i.g. upon challenge once daily for 3 days. 300 mg/kg T-705 administered via i.g. was used as a positive control.

    Punicalagin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Sep 3.  [Abstract]

    T-705 and SAA significantly reduced viral copies in the liver in Female BALB/c mice aged 6–8 weeks after treatment with 20 mg/kg of Salvianolic acid A (SAA), Chebulinic Acid, Tannic acid, or Punicalagin via i.g. upon challenge once daily for 3 days. 300 mg/kg T-705 administered via i.g. was used as a positive control.

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330.  [Abstract]

    Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. The mRNA expression of the inflammatory factors Ccl6, Lgals3, C1qa, TYROBP, and CD74 in the brain tissues 48 h postoperatively, normalized to GAPDH for each sample. PUN can effectively reduce the inflammatory response in brain tissue after HIE, while the AKT signaling pathway inhibitor 3-MA reversed this therapeutic effect.

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330.  [Abstract]

    Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative images of HE staining in the cortex post-operatively.

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330.  [Abstract]

    Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative Western blot images and quantification of Bcl-2 and Bax expression three days post-operation in the cortex.

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330.  [Abstract]

    Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative TUNEL-stained (green) and DAPI-stained (blue) brain sections of the cortex three days post-operatively. Quantitative analysis of the percentage of TUNEL-positive cells in the cortex.

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330.  [Abstract]

    Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative images of immunohistochemical staining of p-AKT and immunofluorescence staining for p62 (red) and LC3 (green) in the cortex of each group at 72 h post-HI.

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    • 参考文献

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    製品説明

    Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19[1][2][3].

    体外実験

    Punicalagin (100 mg/ml) induces apoptosis in HT-29, HCT116 colon cells[1].
    Punicalagin slightly inhibits the PLpro activity with an IC50 of over 50 μM. Punicalagin inhibits the plaque formation of SARS-CoV-2 in a dose-dependent manner, with EC50 values of 7.20 μM[4].
    Punicalagin binds at an allosteric site in the dimer interface. Punicalagin inhibit SARS-CoV-2 replication by a mechanism other than preventing S-mediated viral entry[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    プニカラギン 関連抗体
    体内実験

    Punicalagin (10 mg/kg) inhibits the edema rate of 58.15% in rats[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    1084.72

    分子式

    C48H28O30
    CAS 番号
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(C1=C(C2=C(O)C(O)=C(O)C=C2C(O[C@@H]3[C@@H](CO4)OC(O)[C@H](OC5=O)[C@H]3OC(C6=CC(O)=C(O)C(O)=C6C7=C5C=C(O)C(O)=C7O)=O)=O)C(O)=C8O)OC(C(C1=C8O9)=C%10C9=O)=C(O)C(O)=C%10C%11=C(C4=O)C=C(O)C(O)=C%11O
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (92.19 mM; Need ultrasonic)

    DMSO : 50 mg/mL (46.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.9219 mL 4.6095 mL 9.2190 mL
    5 mM 0.1844 mL 0.9219 mL 1.8438 mL
    10 mM 0.0922 mL 0.4609 mL 0.9219 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.17 mg/mL (2.00 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.17 mg/mL (2.00 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.90%

    COA (264 KB) HNMR (389 KB) LCMS (98 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 0.9219 mL 4.6095 mL 9.2190 mL 23.0474 mL
    5 mM 0.1844 mL 0.9219 mL 1.8438 mL 4.6095 mL
    10 mM 0.0922 mL 0.4609 mL 0.9219 mL 2.3047 mL
    15 mM 0.0615 mL 0.3073 mL 0.6146 mL 1.5365 mL
    20 mM 0.0461 mL 0.2305 mL 0.4609 mL 1.1524 mL
    25 mM 0.0369 mL 0.1844 mL 0.3688 mL 0.9219 mL
    30 mM 0.0307 mL 0.1536 mL 0.3073 mL 0.7682 mL
    40 mM 0.0230 mL 0.1152 mL 0.2305 mL 0.5762 mL
    H2O 50 mM 0.0184 mL 0.0922 mL 0.1844 mL 0.4609 mL
    60 mM 0.0154 mL 0.0768 mL 0.1536 mL 0.3841 mL
    80 mM 0.0115 mL 0.0576 mL 0.1152 mL 0.2881 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Punicalagin Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Punicalagin65995-63-3SARS-CoVHBVSARS coronavirusHepatitis B virusAntioxidantpolyphenolingredientPomegranateantioxidantanti-inflammatoryanticancerInhibitorinhibitorinhibit

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