2. Apoptosis Others
  3. Drug Isomer Bcl-2 Family
  4. (R,R)-S63845

(R,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1.

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(R,R)-S63845

(R,R)-S63845 構造式

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 219 在庫あり
Solution
10 mM * 1 mL in DMSO USD 219 在庫あり
Solid
5 mg $120 在庫あり
10 mg $180 在庫あり
25 mg $350 在庫あり
50 mg $560 在庫あり
100 mg $890 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 0 publication(s) in Google Scholar

Other Forms of (R,R)-S63845:

(R,R)-S63845 関連抗体

Top Publications Citing Use of Products

Bcl-2 Family アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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製品説明

(R,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1[1].

Cellular Effect
Cell Line Type Value Description References
B-lymphoblastic leukemic cell line IC50
<100 nM
Compound: S63845
Anticancer activity against human T-lymphoblastic leukemic cell line assessed as reduction in cell viability
Anticancer activity against human T-lymphoblastic leukemic cell line assessed as reduction in cell viability
[PMID: 33253879]
Leukemia cell IC50
<100 nM
Compound: S63845
Anticancer activity against human leukemia cell assessed as reduction in cell viability
Anticancer activity against human leukemia cell assessed as reduction in cell viability
[PMID: 33253879]
Lymphoma cell line IC50
<100 nM
Compound: S63845
Anticancer activity against human Lymphoma cell line assessed as reduction in cell viability
Anticancer activity against human Lymphoma cell line assessed as reduction in cell viability
[PMID: 33253879]
NCI-H929 GI50
<10 nM
Compound: S63845
Antiproliferative activity against Mcl1-sensitive human NCI-H929 cells
Antiproliferative activity against Mcl1-sensitive human NCI-H929 cells
[PMID: 30929420]
NCI-H929 IC50
6 nM
Compound: 5e
Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33146521]
分子量

829.26

分子式

C39H37ClF4N6O6S
Appearance

Solid

Color

Light brown to yellow

SMILES

OC([C@H](OC1=C2[C@@]([C@@]3=C(C)C(Cl)=C(OCCN4CCN(CC4)C)C=C3)=C(SC2=NC=N1)C5=CC=C(O5)F)CC6=C(OCC7=CC=NN7CC(F)(F)F)C=CC=C6)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (120.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2059 mL 6.0295 mL 12.0589 mL
5 mM 0.2412 mL 1.2059 mL 2.4118 mL
10 mM 0.1206 mL 0.6029 mL 1.2059 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2059 mL 6.0295 mL 12.0589 mL 30.1474 mL
5 mM 0.2412 mL 1.2059 mL 2.4118 mL 6.0295 mL
10 mM 0.1206 mL 0.6029 mL 1.2059 mL 3.0147 mL
15 mM 0.0804 mL 0.4020 mL 0.8039 mL 2.0098 mL
20 mM 0.0603 mL 0.3015 mL 0.6029 mL 1.5074 mL
25 mM 0.0482 mL 0.2412 mL 0.4824 mL 1.2059 mL
30 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0049 mL
40 mM 0.0301 mL 0.1507 mL 0.3015 mL 0.7537 mL
50 mM 0.0241 mL 0.1206 mL 0.2412 mL 0.6029 mL
60 mM 0.0201 mL 0.1005 mL 0.2010 mL 0.5025 mL
80 mM 0.0151 mL 0.0754 mL 0.1507 mL 0.3768 mL
100 mM 0.0121 mL 0.0603 mL 0.1206 mL 0.3015 mL
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(R,R)-S63845 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-S63845Drug IsomerBcl-2 FamilyInhibitorinhibitorinhibit

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製品名:
(R,R)-S63845
製品番号:
HY-100741C
数量:
MCE 日本正規代理店:

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