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choline-kinase-beta-protein-human-his

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Apoptosis (5) Cholinesterase (ChE) (2) Endogenous Metabolite (1)
By Research Areas:	Cancer (7) Neurological Disease (1)

9

Inhibitors & Agonists

2

Peptides

8

Recombinant Proteins

Targets Recommended: Amyloid-β TGF-β Receptor Beta-secretase TGF-beta/Smad 17β-HSD β-catenin 11β-HSD Beta-lactamase Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

MN58b	Apoptosis	Cancer
MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity .

ACG416B	Others	Cancer
ACG416B (compound 18) is a potent inhibitor of ChoK (choline kinase) with an IC₅₀ of 0.4 μM. ACG416B renders higher ChoK inhibitory and antiproliferative activities against the HT-29 human colon cancer cell .

V-11-0711	Others	Cancer
V-11-0711 is a potent and selective choline kinase alpha (ChoKα) inhibitor with an IC₅₀ of 20 nM. V-11-0711 causes a reversible growth arrest in HeLa cells .

ICL-CCIC-0019	Apoptosis	Cancer
ICL-CCIC-0019 is an inhibitor of choline kinase α (CHKα). ICL-CCIC-0019 induces G1 block, endoplasmic reticulum stress apoptosis in cancer cell lines .

ACG548B	Cholinesterase (ChE)	Neurological Disease
ACG548B (compound 24) is a potent inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC₅₀s of 1.78 and 0.496 μM, respectively. ACG548B has higher AChE affinity and selectivity over BChE and ChoK (choline kinase) .

ChoKα inhibitor-3	Apoptosis	Cancer
ChoKα inhibitor-3 is a sulphur-containing *choline kinase* inhibitor. ChoKα inhibitor-3 can inhibit HChoK α1 with an IC₅₀ value of 0.66 μM. ChoKα inhibitor-3 also can induce apoptosis. ChoKα inhibitor-3 can be used for the research of cancer .

ChoKα inhibitor-5	Apoptosis	Cancer
ChoKα inhibitor-5 is a sulphur-containing *choline kinase* inhibitor. ChoKα inhibitor-5 can inhibit HChoK α1 with an IC₅₀ value of 0.64 μM. ChoKα inhibitor-5 also can induce apoptosis. ChoKα inhibitor-5 can be used for the research of cancer .

EB-3D 1 Publications Verification	AMPK Apoptosis	Cancer
EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC₅₀ of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity .

*His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA*	Endogenous Metabolite Cholinesterase (ChE)	Others
His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, is a growth hormone releasing peptide, as well as a metabolite of GHRP-1. GHRP-1, or Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, has the effect of promoting the release of growth hormone (GH). GHRP-1 increases GH release and increases [Ca2+]i levels in static monolayer cells of rat pituitary gland, but does not affect cAMP levels .

Species:	Human (8)
Tag:	His (8) Avi (1)
Source:	E. coli (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P700090AF

	*Animal-Free IFN-beta Protein, Human* (His)** IFNB1; Type I Interferon	Human	E. coli
	PDGF R beta protein is a receptor protein that binds to platelet-derived growth factor (PDGF). It is expressed in a variety of cells, including fibroblasts and smooth muscle cells. Animal-Free IFN-beta Protein, Human (His) is the recombinant human-derived animal-FreeIFN-beta protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IFN-beta Protein, Human (His) is 166 a.a., with molecular weight of ~20.84 kDa.

	*DNA polymerase beta Protein, Human* (His)** rHuDNA polymerase beta, his; DNA Polymerase beta; POLB	Human	E. coli
	DNA polymerase beta Protein, Human (His), a DNA repair enzyme, is involved in various types of DNA repair. DNA polymerase beta Protein performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance.

	*PKI-beta Protein, Human* (His)** cAMP-Dependent protein kinase Inhibitor beta; PKI-beta; PKIB; PRKACN2	Human	E. coli
	The PKI-β protein emerged as an extremely potent competitive inhibitor of cAMP-dependent protein kinase activity. This protein operates at the molecular level, binding to the catalytic subunit of the enzyme after cAMP induces dissociation of its regulatory chain. PKI-beta Protein, Human (His) is the recombinant human-derived PKI-beta protein, expressed by E. coli , with N-6*His labeled tag. The total length of PKI-beta Protein, Human (His) is 78 a.a., with molecular weight of ~14.0 kDa.

	*14-3-3 beta Protein, Human* (His)** KCIP-1; 14-3-3 protein beta/alpha; GW128; protein 1054; YWHAB	Human	E. coli
	14-3-3 beta protein, functioning as an adapter, regulates diverse signaling pathways by recognizing phosphoserine or phosphothreonine motifs and modulating partner activity. It acts as a negative regulator in osteogenesis, inhibiting SRPK2's nuclear translocation and preventing neuronal apoptosis. Additionally, it negatively regulates MAP kinase-activating cascades through AKAP13. As a homodimer, it interacts with various proteins, emphasizing its diverse roles in cellular processes and signaling pathways. 14-3-3 beta Protein, Human (His) is the recombinant human-derived 14-3-3 beta protein, expressed by E. coli, with N-6*His labeled tag. The total length of 14-3-3 beta Protein, Human (His) is 246 a.a., with molecular weight of ~29 kDa.

	*IL-1 beta Protein, Human* (His, E6K)** Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (His) is produced in E. coli with a N-Terminal His-tag. It consists of 269 amino acids (M1-S269).

HY-P700100AF

	*Animal-Free IL-12 beta Protein, Human* (His)** Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; IL12B; NKSF2	Human	E. coli
	IL-12 beta protein is a multifunctional cytokine that serves as a growth factor for activated T cells and NK cells, amplifies the lytic activity of NK/lymphokine-activated killer cells, and induces IFN production by resting peripheral blood mononuclear cells -γ. peripheral blood mononuclear cells). Animal-Free IL-12 beta Protein, Human (His) is the recombinant human-derived animal-FreeIL-12 beta protein, expressed by E. coli , with His labeled tag. The total length of Animal-Free IL-12 beta Protein, Human (His) is 306 a.a., with molecular weight of ~35.64 kDa.

	*IL-1 beta Protein, Human* (His-Avi)** Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (His-Avi) is produced in E. coli with a C-Terminal His-tag and a C-Terminal Avi-tag. It consists of 153 amino acids (A117-S269).

HY-P700096AF

	*Animal-Free IL-1 beta Protein, Human* (His)** Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Human	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses. It induces inflammatory events including prostaglandin synthesis, neutrophil activation, and cytokine production. Animal-Free IL-1 beta Protein, Human (His) is the recombinant human-derived animal-FreeIL-1 beta protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-1 beta Protein, Human (His) is 153 a.a., with molecular weight of ~18.48 kDa.

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