1. Apoptosis
  2. Apoptosis
  3. MN58b

MN58b 

Cat. No.: HY-108431
Handling Instructions

MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity.

For research use only. We do not sell to patients.

MN58b Chemical Structure

MN58b Chemical Structure

CAS No. : 203192-01-2

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Description

MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity[1][2].

IC50 & Target

Choline kinase α (CHKα)[1]

In Vitro

The IC50s of MN58b for parental and Gemcitabine-resistant Suit2 007 cells are 3.14 µM and 0.77 µM, respectively[1].
MN58b (1-5 µM; 72 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) has a marked effect on colony formation at 1 µM, and growth is completely abolished at 5 µM in all the cell lines[1].
MN58b ((1-10 µM; 24-48 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) induces apoptosis and this response correlates with CHKα expression[1].

Cell Viability Assay[1]

Cell Line: SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells
Concentration: 1 µM, 5 µM
Incubation Time: 72 hours
Result: Inhibited cells growth.

Apoptosis Analysis[1]

Cell Line: SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells
Concentration: 1 µM, 2 µM, 5 µM, 10 µM
Incubation Time: 24 and 48 hours
Result: Induced cell apoptosis.
In Vivo

MN58b (4 mg/kg; intraperitoneal injection; once a day; for 5 days; MF-1 nude mice) treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities[2].

Animal Model: MF-1 nude mice with HT29 or MDA-MB-231 cells[2]
Dosage: 4 mg/kg
Administration: Intraperitoneal injection; once a day; for 5 days
Result: Phosphomonoesters decreased significantly.
Molecular Weight

640.49

Formula

C₃₂H₄₀Br₂N₄

CAS No.

203192-01-2

SMILES

CN(C)C1=CC=[N+](C=C1)CC2=CC=C(CCCCC3=CC=C(C[N+]4=CC=C(N(C)C)C=C4)C=C3)C=C2.[Br-].[Br-]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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