203192-01-2
203192-01-2
Chemical Structure
MN58b
- CAS No.: 203192-01-2
- Formula:C32H40Br2N4
- Molecular Weight:640.49
IUPAC Name: 1,1'-((butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide
InChIKey: YLHINOUDZGYMNO-UHFFFAOYSA-L
SMILES: CN(C)C1=CC=[N+](C=C1)CC2=CC=C(CCCCC3=CC=C(C[N+]4=CC=C(N(C)C)C=C4)C=C3)C=C2.[Br-].[Br-]
Biological Activity: MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MN58b | 99.78% | MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.77
HY-115463EB-3D -
Similarity Score 0.62
![4,4'-Bipyridinium,1,1'-bis[(4-carboxyphenyl)methyl]-,bromide(1:2) Chemical Structure](//file.medchemexpress.com/product_pic/hy-w543294.gif)
HY-W5432944,4'-Bipyridinium,1,1'-bis[(4-carboxyphenyl)methyl]-,bromide(1:2) -
Similarity Score 0.62
![1,1'-[1,4-Phenylenebis(methylene)]bis(4,4'-bipyridinium) dibromide Chemical Structure](//file.medchemexpress.com/product_pic/hy-21594.gif)
HY-215941,1'-[1,4-Phenylenebis(methylene)]bis(4,4'-bipyridinium) dibromide -
Similarity Score 0.61
![4,4'-([4,4'-Bipyridine]-1,1'-diium-1,1'-diylbis(methylene))dibenzoate Chemical Structure](//file.medchemexpress.com/product_pic/hy-w1049903.gif)
HY-W10499034,4'-([4,4'-Bipyridine]-1,1'-diium-1,1'-diylbis(methylene))dibenzoate -
Similarity Score 0.61
![4,4′-Bipyridinium, 1,1′-bis[(4-carboxyphenyl)methyl] dichloride Chemical Structure](//file.medchemexpress.com/product_pic/hy-w586966.gif)
HY-W5869664,4′-Bipyridinium, 1,1′-bis[(4-carboxyphenyl)methyl] dichloride -
Similarity Score 0.60
![1,1'-([1,1'-Biphenyl]-4,4'-diylbis(methylene))bis(4-carboxypyridin-1-ium) chloride Chemical Structure](//file.medchemexpress.com/product_pic/hy-w1049913.gif)
HY-W10499131,1'-([1,1'-Biphenyl]-4,4'-diylbis(methylene))bis(4-carboxypyridin-1-ium) chloride -
Similarity Score 0.60
![1,1''-(1,4-Phenylenebis(methylene))bis(([4,4'-bipyridin]-1-ium)) Chemical Structure](//file.medchemexpress.com/product_pic/hy-w248992.gif)
HY-W2489921,1''-(1,4-Phenylenebis(methylene))bis(([4,4'-bipyridin]-1-ium)) -
Similarity Score 0.58
![Pyridinium, 1,1′-[1,4-phenylenebis(methylene)]bis[4-carboxy-, bromide (1:2) Chemical Structure](//file.medchemexpress.com/product_pic/hy-w586865.gif)
HY-W586865Pyridinium, 1,1′-[1,4-phenylenebis(methylene)]bis[4-carboxy-, bromide (1:2) -
Similarity Score 0.58
HY-115840ICL-CCIC-0019 -
Explore the MedChemAI to find more analogs
![4,4'-Bipyridinium,1,1'-bis[(4-carboxyphenyl)methyl]-,bromide(1:2) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w543294.gif)
![1,1'-[1,4-Phenylenebis(methylene)]bis(4,4'-bipyridinium) dibromide Chemical Structure](http://file.medchemexpress.com/product_pic/hy-21594.gif)
![4,4'-([4,4'-Bipyridine]-1,1'-diium-1,1'-diylbis(methylene))dibenzoate Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w1049903.gif)
![4,4′-Bipyridinium, 1,1′-bis[(4-carboxyphenyl)methyl] dichloride Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w586966.gif)
![1,1'-([1,1'-Biphenyl]-4,4'-diylbis(methylene))bis(4-carboxypyridin-1-ium) chloride Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w1049913.gif)
![1,1''-(1,4-Phenylenebis(methylene))bis(([4,4'-bipyridin]-1-ium)) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w248992.gif)
![Pyridinium, 1,1′-[1,4-phenylenebis(methylene)]bis[4-carboxy-, bromide (1:2) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w586865.gif)
References
- [1]. Mazarico JM, et al. Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors. Mol Cancer Ther. 2016 Feb;15(2):323-33. [Content Brief]
- [2]. Al-Saffar NM, et al. Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models. Cancer Res. 2006 Jan 1;66(1):427-34. [Content Brief]
