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AP1 Transcription Factor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AP-1 (9) Apoptosis (4) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (1) Drug Metabolite (3) Environmental Pollutants (1) Fungal (1) Insecticide (3) Isotope-Labeled Compounds (1) mGluR (1) MMP (3) mRNA (1) Necroptosis (3) NF-κB (2) Reference Standards (1)
By Research Areas:	Cancer (10) Infection (4) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (5)
Oligonucleotides:	mRNA (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: AP-1 Microphthalmia Associated Transcription Factor (MITF) AAK1 OLIG2 ATF6 MetAP RUNX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12270

T-5224 Maximum Cited Publications 100 Publications Verification	AP-1 MMP	Neurological Disease Inflammation/Immunology Cancer
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-15870

SR 11302 20+ Cited Publications	AP-1	Inflammation/Immunology Cancer
SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) .

HY-129239

Farudodstat 4 Publications Verification ASLAN003	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Apoptosis	Cancer
Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC₅₀ of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice .

HY-122808

(-)-Camphoric acid	mGluR NF-κB AP-1	Metabolic Disease
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid induces glutamate receptor expression. Camphoric acid also significantly induces the activation of NF-κB and *AP-1. Camphoric acid significantly stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Camphoric acid has weak regulatory function towards glutamate receptors. Camphoric acid can induce mRNA expression of glutamate signaling molecules and activate transcription* factors, thereby stimulating osteoblast differentiation .

HY-N1513

Ganoderic acid H	AP-1 NF-κB	Cancer
Ganoderic acid H is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderic acid H suppresses growth and invasive behavior of breast cancer cells through the inhibition of transcription factors AP-1 and NF-kappaB signaling .

HY-B1984

p,p'-DDD 1 Publications Verification 4,4'-DDD; p,p'-Dichlorodiphenyl dichloroethane	Environmental Pollutants Drug Metabolite Apoptosis Insecticide Necroptosis	Infection Neurological Disease Cancer
p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-15870A

(6E)-SR 11302	AP-1	Inflammation/Immunology Cancer
(6E)-SR 11302 is a E-isomer of SR 11302. SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) .

HY-12270R

T-5224 (Standard)	AP-1 MMP	Others
T-5224 (Standard) is the analytical standard of T-5224. This product is intended for research and analytical applications. T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-B1984S

p,p'-DDD-d8 4,4'-DDD-d₈; p,p'-Dichlorodiphenyl dichloroethane-d₈	Drug Metabolite Apoptosis Necroptosis Insecticide	Infection Neurological Disease Cancer
p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-174682

Human FOS mRNA	mRNA	Cancer
Human FOS mRNA encodes the human Fos proto-oncogene, AP-1 transcription factor subunit (FOS) protein which has been implicated as regulators of cell proliferation, differentiation, and transformation.

HY-169751

Dihydro-N-caffeoyltyramine	Fungal AP-1	Infection Inflammation/Immunology Cancer
Dihydro-N-caffeoyltyramine is a new phenolic amide that can be isolated from the root bark of wolfberry and has strong antioxidant activity and antifungal effects. Dihydro-N-caffeoyltyramine downregulates the expression of cyclooxygenase-2 by inhibiting the activity of C/EBP and AP-1 transcription factors .

HY-179594

HTS10307	AP-1	Neurological Disease
HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC₅₀ values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease .

HY-B1984R

p,p'-DDD (Standard) 4,4'-DDD (Standard); p,p'-Dichlorodiphenyl dichloroethane (Standard)	Reference Standards Drug Metabolite Apoptosis Necroptosis Insecticide	Infection Neurological Disease Cancer
p,p'-DDD (Standard) is the analytical standard of p,p'-DDD (HY-B1984) . This product is intended for research and analytical applications. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats.

HY-12270S

T-5224-d8	Isotope-Labeled Compounds AP-1 MMP	Inflammation/Immunology
T-5224-d₈ is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Cat. No.	Product Name

HY-L090

Transcription Factor-Targeted Library	2,427 compounds
Transcription is the essential first step in the conversion of the genetic information in the DNA into protein and the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II and an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation and responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders and cardiovascular disease to many cancers, and thus these proteins hold great therapeutic potential. MCE offers a unique collection of 2,427 compounds with validated transcription factor targets modulating properties. MCE transcription factor-targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

Transcription Factor-Targeted Library

2,427 compounds

Transcription is the essential first step in the conversion of the genetic information in the DNA into protein and the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II and an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation and responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders and cardiovascular disease to many cancers, and thus these proteins hold great therapeutic potential.

MCE offers a unique collection of 2,427 compounds with validated transcription factor targets modulating properties. MCE transcription factor-targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122808

(-)-Camphoric acid	Classification of Application Fields Ketones, Aldehydes, Acids Cinnamomum glanduliferum (Wall.) Nees Metabolic Disease Plants Lauraceae Disease Research Fields Source Classification	mGluR NF-κB AP-1
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid induces glutamate receptor expression. Camphoric acid also significantly induces the activation of NF-κB and *AP-1. Camphoric acid significantly stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Camphoric acid has weak regulatory function towards glutamate receptors. Camphoric acid can induce mRNA expression of glutamate signaling molecules and activate transcription* factors, thereby stimulating osteoblast differentiation .

HY-N1513

Ganoderic acid H	Triterpenes Microorganisms Classification of Application Fields Terpenoids Polyporaceae Plants Disease Research Fields Cancer Source Classification	AP-1 NF-κB
Ganoderic acid H is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderic acid H suppresses growth and invasive behavior of breast cancer cells through the inhibition of transcription factors AP-1 and NF-kappaB signaling .

Species:	Human (2) Mouse (1)
Tag:	His (3) Myc (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702589

	JUN Protein, Human (His, Myc) Activator protein 1; AP1; Proto-oncogene c-Jun; Transcription Factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	Human	E. coli
	JUN Protein, Human (His, Myc) is the recombinant human-derived JUN, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P706013

	FOSB Protein, Mouse (His) FBJ osteosarcoma oncogene B; Transcription Factor AP-1 subunit FosB; Protein FosB; Fosb	Mouse	E. coli

HY-P7S2617

	FOSB Protein, Human (His) FBJ osteosarcoma oncogene B; Transcription Factor AP-1 subunit FosB; Protein FosB; Fosb	Human	E. coli

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Cat. No.	Product Name	Chemical Structure

HY-B1984S

p,p'-DDD-d8
p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

p,p'-DDD-d8

p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-12270S

T-5224-d8
T-5224-d₈ is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Host:	Rabbit (10)
Reactivity:	Human (10) Rat (9) Mouse (9)
Application:	IHC-P (7) ICC/IF (3) IF-Tissue (2) IP (5) WB (10) ChIP (1) FC (1)
Isotype:	IgG (10)
Conjugation:	Non-conjugated (10)
Clonality:	Polyclonal (2) Monoclonal (6) Recombinant (6)
Modification:	Phosphorylated (5) Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80800

	Phospho-c-Jun (Ser243) Antibody Transcription Factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser243) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-c-Jun (Ser243).

HY-P80802

	Phospho-c-Jun (Ser73) Antibody Transcription Factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser73) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-c-Jun (Ser73).

HY-P82861

	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) JUN; Transcription Factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39; JUND; Transcription Factor jun-D	WB, IP	Human, Mouse, Rat
	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Jun/JunD (Ser73/Ser100).

HY-P80801

	Phospho-c-Jun (Ser63) Antibody (YA215) Transcription Factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser63) Antibody (YA215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-c-Jun (Ser63).

HY-P82861A

	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606)(PBS only) JUN; Transcription Factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39; JUND; Transcription Factor jun-D	WB, IP	Human, Mouse, Rat
	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Jun/JunD (Ser73/Ser100).

HY-P80801A

	Phospho-c-Jun (Ser63) Antibody (YA215)(PBS only) Transcription Factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser63) Antibody (YA215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-c-Jun (Ser63).

HY-P810403

	JunD Antibody (YA9718) Activator protein 1, AP 1, AP1, Jun D, jun D proto oncogene, Jund, JunD FL isoform, JUND_HUMAN, Transcription Factor jun D, Transcription Factor jun-D	WB, ICC/IF, IHC-P, ChIP, IP	Human, Mouse, Rat
	JunD Antibody (YA9718) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to JunD.

HY-P810404

	JunD Antibody (YA9719) Activator protein 1, AP 1, AP1, Jun D, jun D proto oncogene, Jund, JunD FL isoform, JUND_HUMAN, Transcription Factor jun D, Transcription Factor jun-D	WB, ICC/IF, IF-Tissue, IP, IHC-P, FC	Human
	JunD Antibody (YA9719) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to JunD.

HY-P810402

	Phospho-JunD (Ser255) Antibody (YA9717) Activator protein 1, AP 1, AP1, Jun D, jun D proto oncogene, Jund, JunD FL isoform, JUND_HUMAN, Transcription Factor jun D, Transcription Factor jun-D	WB, ICC/IF, IF-Tissue, IHC-P	Human, Mouse, Rat
	Phospho-JunD (Ser255) Antibody (YA9717) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Phospho-JunD(Ser255).

HY-P83342

	Phospho-JunD (Ser255) Antibody (YA3087) Activator protein 1; AP 1; Jun D; jun D proto oncogene; Jund; JunD FL isoform; Transcription Factor jun D	WB, IP	Human, Mouse, Rat
	Phospho-JunD (Ser255) Antibody (YA3087) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-JunD (Ser255).