EV-71

By Targets:	Bacterial (1) Cholinesterase (ChE) (1) Enterovirus (16) Fluorescent Dye (1) Glucosidase (1) Opioid Receptor (1)
By Research Areas:	Cancer (1) Infection (15) Inflammation/Immunology (2) Neurological Disease (1)

Targets Recommended: Transferrin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W016407

Methyl 3,4-dihydroxyphenylacetate	Enterovirus	Infection
Methyl 3,4-dihydroxyphenylacetate is a potent enterovirus 71 (EV71) infection inhibitor. Methyl 3,4-dihydroxyphenylacetate inhibits EV71 replication in rhabdomyosarcoma (RD) cells .

HY-125713

Ganoderic acid Y	Glucosidase Enterovirus	Infection
Ganoderic acid Y is a α-glucosidase inhibitor with an IC₅₀ of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits *enterovirus 71 (EV71) replication* through blocking EV71 uncoating .

HY-N2036

Mosloflavone	Enterovirus Bacterial	Infection
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with anti-EV71 activity. Mosloflavone inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

HY-157082

ZHSI-1	Enterovirus	Infection
ZHSI-1 is an *EV71* (Enterovirus 71) inhibitor that inhibits EV71/CVA16 replication and virus-induced pyroptosis associated with viral pathogenesis. ZHSI-1 effectively prevents EV71 infection in neonatal and young mice in animal models. ZHSI-1 can be used to study viral infections such as hand, foot and mouth disease (HFMD) .

HY-106254

Vapendavir BTA798	Enterovirus	Infection
Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC₅₀ values of 0.5-1.4 μM in different EV71 strains .

HY-147700

Antiviral agent 21

Enterovirus Infection

Antiviral agent 21 (Compound 4) is an anti-EV71 agent .

Antiviral agent 21	Enterovirus	Infection
Antiviral agent 21 (Compound 4) is an anti-EV71 agent .

HY-106254A

Vapendavir diphosphate 3 Publications Verification BTA798 diphosphate	Enterovirus	Infection Inflammation/Immunology
Vapendavir diphosphate (BTA798 diphosphate) is a potent enteroviral capsid binder (CB). Vapendavir diphosphate (BTA798 diphosphate) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC₅₀ values of 0.5-1.4 μM in different EV71 strains .

HY-128382

Brilliant Black BN E 151	Enterovirus	Infection
Brilliant black BN (E151) is an azo dye and a food colorant . Brilliant black BN is a promising antiviral agent against *EV71* infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN has the potential for the investigation of contagious disease .

HY-N0306

Hederasaponin B

Enterovirus Infection

Hederasaponin B, isolated from Hedera helix, has broad-spectrum antiviral activity against various subgenotypes of Enterovirus 71 (EV71).
HY-120900

AN-12-H5

Enterovirus Infection Inflammation/Immunology

AN-12-H5, an antienterovirus compound, targets the replication processes of PV and enterovirus 71 (EV71) .

Hederasaponin B	Enterovirus	Infection
Hederasaponin B, isolated from Hedera helix, has broad-spectrum antiviral activity against various subgenotypes of Enterovirus 71 (EV71).

AN-12-H5	Enterovirus	Infection Inflammation/Immunology
AN-12-H5, an antienterovirus compound, targets the replication processes of PV and enterovirus 71 (EV71) .

HY-N2562

Norwogonin 5,7,8-Trihydroxyflavone	Enterovirus	Infection
Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC₅₀ of 31.83 μg/ml

HY-145932

DMA-135 hydrochloride	Enterovirus	Infection
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (K_D= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies . DMA-135 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16561A

cis-Resveratrol	Enterovirus	Infection
cis-Resveratrol exhibits signifcant antiviral activity. cis-Resveratrol inhibits enteroviruses with IC₅₀s of 12.2 µM and 37.6 µM for coxsackievirus B3 (CVB3) and enterovirus 71 (EV71), respectively .

HY-151924

Antiviral agent 23	Enterovirus	Infection
Antiviral agent 23 (compound 11b) is an antiviral agent to enterovirus 71 (EV71) with an EC₅₀ value of 94 nM. Antiviral agent 23 effectively suppresses the activity of METTL3/METTL14. Antiviral agent 23 can be used for the research of infection .

HY-151926

Antiviral agent 24	Enterovirus	Infection
Antiviral agent 24 is a potent antiviral agent with EC₅₀ values of 0.101, 19.9, 91.2 µM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner .

HY-N0923

Corydaline (+)-Corydaline; Corydalin	Cholinesterase (ChE) Enterovirus Opioid Receptor	Neurological Disease
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 µM. Corydaline is a μ-opioid receptor (K_i of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

HY-W127716

Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2	Fluorescent Dye	Cancer
Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can bu used as an effective quencher of quantum dots (QDs) fluorescence and the capture probe of virus antigen EV71. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can be used sensitive electrogenerated chemiluminescence (ECL) labels for detection of matrix metalloproteinases (MMPs) .

Cat. No.	Product Name	Type

HY-128382

Brilliant Black BN E 151	Dyes
Brilliant black BN (E151) is an azo dye and a food colorant . Brilliant black BN is a promising antiviral agent against *EV71* infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN has the potential for the investigation of contagious disease .

HY-W127716

Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2	Fluorescent Dyes/Probes
Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can bu used as an effective quencher of quantum dots (QDs) fluorescence and the capture probe of virus antigen EV71. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can be used sensitive electrogenerated chemiluminescence (ECL) labels for detection of matrix metalloproteinases (MMPs) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125713

Ganoderic acid Y	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields	Glucosidase Enterovirus
Ganoderic acid Y is a α-glucosidase inhibitor with an IC₅₀ of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits *enterovirus 71 (EV71) replication* through blocking EV71 uncoating .

HY-N2036

Mosloflavone	Infection Flavonoids Monophenols Scutellaria baicalensis Georgi Classification of Application Fields Flavones Labiatae Source classification Phenols Plants Disease Research Fields	Enterovirus Bacterial
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with anti-EV71 activity. Mosloflavone inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

HY-N0306

Hederasaponin B	Infection Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Enterovirus
Hederasaponin B, isolated from Hedera helix, has broad-spectrum antiviral activity against various subgenotypes of Enterovirus 71 (EV71).

HY-N2562

Norwogonin 5,7,8-Trihydroxyflavone	Infection Flavonoids Scutellaria baicalensis Georgi Classification of Application Fields Flavones Labiatae Source classification Phenols Polyphenols Plants Disease Research Fields	Enterovirus
Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC₅₀ of 31.83 μg/ml

HY-16561A

cis-Resveratrol	Infection other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Enterovirus
cis-Resveratrol exhibits signifcant antiviral activity. cis-Resveratrol inhibits enteroviruses with IC₅₀s of 12.2 µM and 37.6 µM for coxsackievirus B3 (CVB3) and enterovirus 71 (EV71), respectively .

HY-N0923

Corydaline (+)-Corydaline; Corydalin	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Cholinesterase (ChE) Enterovirus Opioid Receptor
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 µM. Corydaline is a μ-opioid receptor (K_i of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

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EV-71

Inhibitors & Agonists

Fluorescent Dye

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