2. Anti-infection
  3. Enterovirus
  4. Vapendavir

Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains.

For research use only. We do not sell to patients.

Vapendavir

Vapendavir Chemical Structure

CAS No. : 439085-51-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 4 publication(s) in Google Scholar

Other Forms of Vapendavir:

Vapendavir Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains[1][2].

IC50 & Target

EC50: 0.5-1.4 μM (EV71 strains)[1][2].
Cellular Effect
Cell Line Type Value Description References
HeLa EC50
0.001 μg/mL
Compound: 6, BTA798
Antirhinoviral activity against Human rhinovirus 2 infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
Antirhinoviral activity against Human rhinovirus 2 infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
[PMID: 24900468]
HeLa EC50
0.005 μg/mL
Compound: 6, BTA798
Antirhinoviral activity against Human rhinovirus 14 infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
Antirhinoviral activity against Human rhinovirus 14 infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
[PMID: 24900468]
HeLa EC50
1.9 ng/mL
Compound: 6, BTA798
Antirhinoviral activity against minor receptor-resistant Human rhinovirus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
Antirhinoviral activity against minor receptor-resistant Human rhinovirus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
[PMID: 24900468]
HeLa EC50
2.7 ng/mL
Compound: 6, BTA798
Antirhinoviral activity against antiviral-resistant Human rhinovirus B infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
Antirhinoviral activity against antiviral-resistant Human rhinovirus B infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
[PMID: 24900468]
HeLa EC50
3.8 ng/mL
Compound: 6, BTA798
Antirhinoviral activity against Human rhinovirus A infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
Antirhinoviral activity against Human rhinovirus A infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
[PMID: 24900468]
HeLa EC50
5.2 ng/mL
Compound: 6, BTA798
Antirhinoviral activity against major receptor-resistant Human rhinovirus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
Antirhinoviral activity against major receptor-resistant Human rhinovirus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
[PMID: 24900468]
HeLa EC50
5.7 ng/mL
Compound: 6, BTA798
Antirhinoviral activity against antiviral-resistant Human rhinovirus A infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
Antirhinoviral activity against antiviral-resistant Human rhinovirus A infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
[PMID: 24900468]
HeLa EC50
5 ng/mL
Compound: 6, BTA798
Antirhinoviral activity against Human rhinovirus B infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
Antirhinoviral activity against Human rhinovirus B infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
[PMID: 24900468]
MRC5 CC50
> 20 μM
Compound: Vapendavir
Cytotoxicity against human MRC5 cells
Cytotoxicity against human MRC5 cells
[PMID: 39088999]
RD CC50
> 63 μM
Compound: Vapendavir
Cytotoxicity against human RD cells
Cytotoxicity against human RD cells
[PMID: 39088999]
In Vitro

Vapendavir (BTA798) efficiently inhibit the in vitro replication of 21 EV71 strains/isolates that are representative of the different genogroups A, B, and C[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vapendavir Related Antibodies
Clinical Trial
Molecular Weight

382.46

Formula

C21H26N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCOC1=NOC2=CC(OCCC3CCN(C4=CC=C(C)N=N4)CC3)=CC=C12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (13.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6147 mL 13.0733 mL 26.1465 mL
5 mM 0.5229 mL 2.6147 mL 5.2293 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6147 mL 13.0733 mL 26.1465 mL 65.3663 mL
5 mM 0.5229 mL 2.6147 mL 5.2293 mL 13.0733 mL
10 mM 0.2615 mL 1.3073 mL 2.6147 mL 6.5366 mL
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Vapendavir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vapendavir439085-51-5BTA798BTA 798BTA-798EnterovirusRhinovirusHRVHRVsHEVHEVsInhibitorinhibitorinhibit

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