1. Neuronal Signaling
    Anti-infection
    GPCR/G Protein
  2. AChE
    Enterovirus
    Opioid Receptor
  3. Corydaline

Corydaline (Synonyms: (+)-Corydaline; Corydalin)

Cat. No.: HY-N0923 Purity: 96.17%
Handling Instructions

Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 µM. Corydaline is a μ-opioid receptor (Ki of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.

For research use only. We do not sell to patients.

Corydaline Chemical Structure

Corydaline Chemical Structure

CAS No. : 518-69-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 264 In-stock
Estimated Time of Arrival: December 31
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Description

Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 µM. Corydaline is a μ-opioid receptor (Ki of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities[1][2][3].

IC50 & Target

IC50: 226 µM (AChE)[1]; 25.23 µM (Enterovirus 71)[2]
Ki: 1.23 µM (μ-opioid receptor)[3]

In Vitro

Corydaline (12.5-50 µM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro[2].
Corydaline could inhibit the viral RNA synthesis in a dose dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Vero cells infected with EV71
Concentration: 12.5 µM, 25 µM, 50 µM
Incubation Time: 24 hours
Result: Reduced the phosphorylation of P38 MAPK and JNK MAPK and the expression of COX-2.
In Vivo

Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid[3]
Dosage: 10 mg/kg
Administration: Subcutaneous administration; once
Result: Showed antinociceptive effects in mice.
Molecular Weight

369.45

Formula

C₂₂H₂₇NO₄

CAS No.

518-69-4

SMILES

C[[email protected]@H](C1=CC=C2OC)[[email protected]]3([H])C4=CC(OC)=C(OC)C=C4CCN3CC1=C2OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (90.22 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7067 mL 13.5336 mL 27.0673 mL
5 mM 0.5413 mL 2.7067 mL 5.4135 mL
10 mM 0.2707 mL 1.3534 mL 2.7067 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Corydaline(+)-Corydaline CorydalinAChEEnterovirusOpioid ReceptorAcetylcholinesteraseRhinovirusHRVHRVsHEVHEVsAntiacetylcholinesteraseantiallergicantinociceptiveantibutylcholinesteraseEV71COX-2oral,Inhibitorinhibitorinhibit

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Corydaline
Cat. No.:
HY-N0923
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