2. Neuronal Signaling Anti-infection GPCR/G Protein
  3. Cholinesterase (ChE) Enterovirus Opioid Receptor
  4. Corydaline

Corydaline  (Synonyms: (+)-Corydaline; Corydalin)

Cat. No.: HY-N0923 Purity: 99.70%
COA Handling Instructions

Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 µM. Corydaline is a μ-opioid receptor (Ki of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.

For research use only. We do not sell to patients.

Corydaline Chemical Structure

Corydaline Chemical Structure

CAS No. : 518-69-4

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Solid + Solvent
10 mM * 1 mL in DMSO
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Corydaline Related Antibodies

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Description

Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 µM. Corydaline is a μ-opioid receptor (Ki of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities[1][2][3].

IC50 & Target

AChE

 

μ Opioid Receptor/MOR

 

In Vitro

Corydaline (12.5-50 µM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro[2].
Corydaline could inhibit the viral RNA synthesis in a dose dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Corydaline Related Antibodies

Western Blot Analysis[2]

Cell Line: Vero cells infected with EV71
Concentration: 12.5 µM, 25 µM, 50 µM
Incubation Time: 24 hours
Result: Reduced the phosphorylation of P38 MAPK and JNK MAPK and the expression of COX-2.
In Vivo

Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid[3]
Dosage: 10 mg/kg
Administration: Subcutaneous administration; once
Result: Showed antinociceptive effects in mice.
Molecular Weight

369.45

Appearance

Solid

Formula

C22H27NO4
CAS No.
SMILES

C[C@@H](C1=CC=C2OC)[C@]3([H])C4=CC(OC)=C(OC)C=C4CCN3CC1=C2OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (90.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7067 mL 13.5336 mL 27.0673 mL
5 mM 0.5413 mL 2.7067 mL 5.4135 mL
10 mM 0.2707 mL 1.3534 mL 2.7067 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.77 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.70%

COA (250 KB) HNMR (259 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References
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Corydaline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Corydaline518-69-4(+)-Corydaline CorydalinCholinesterase (ChE)EnterovirusOpioid ReceptorRhinovirusHRVHRVsHEVHEVsAntiacetylcholinesteraseantiallergicantinociceptiveantibutylcholinesteraseEV71COX-2oral,Inhibitorinhibitorinhibit

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