1. Anti-infection
  2. Enterovirus
    Bacterial
  3. Mosloflavone

Mosloflavone 

Cat. No.: HY-N2036
Handling Instructions

Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with  anti-EV71 activity. Mosloflavone  inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

For research use only. We do not sell to patients.

Mosloflavone Chemical Structure

Mosloflavone Chemical Structure

CAS No. : 740-33-0

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Description

Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with  anti-EV71 activity. Mosloflavone  inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

IC50 & Target

IC50: EV71; bacterial[1][2]

In Vitro

Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

298.29

Formula

C₁₇H₁₄O₅

CAS No.

740-33-0

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC(OC)=C(OC)C(O)=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MosloflavoneEnterovirusBacterialRhinovirusHRVHRVsHEVHEVsEnterovirus 71EV-71 biocideP. aeruginosaInhibitorinhibitorinhibit

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Mosloflavone
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HY-N2036
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