Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos

  • Bioorg Med Chem Lett. 2003 May 19;13(10):1813-5. doi: 10.1016/s0960-894x(03)00197-5.
Jiu-Hong Wu  1 ,  Xi-Hong Wang ,  Yang-Hua Yi ,  Kuo-Hsiung Lee
Affiliations
  • 1. Department of Pharmacy, 306 Hospital of PLA, Beijing 100101, China.
PMID: 12729671 DOI: 10.1016/s0960-894x(03)00197-5
Abstract

Sixteen Flavonoids and their derivatives isolated from Desmos spp. were evaluated for inhibition of HIV replication in H9 lymphocyte cells. 2-Methoxy-3-methyl-4,6-dihydroxy-5-(3'-hydroxy)cinnamoylbenzaldehyde (12) and lawinal (6) demonstrated potent anti-HIV activity with EC(50) values of 0.022 and 2.30 microg/mL and therapeutic indexes of 489 and 45.2, respectively. Compound 12 appears to be an excellent lead for further anti-HIV drug development.