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  2. Enterovirus
  3. Brilliant Black BN

Brilliant Black BN (Synonyms: E 151)

Cat. No.: HY-128382 Purity: >98.0%
Handling Instructions

Brilliant black BN (E151) is an azo dye and a food colorant. Brilliant black BN is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN has the potential for the investigation of contagious disease.

For research use only. We do not sell to patients.

Brilliant Black BN Chemical Structure

Brilliant Black BN Chemical Structure

CAS No. : 2519-30-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 149 In-stock
Estimated Time of Arrival: December 31
25 mg USD 135 In-stock
Estimated Time of Arrival: December 31
100 mg USD 395 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Brilliant black BN (E151) is an azo dye and a food colorant[1]. Brilliant black BN is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN has the potential for the investigation of contagious disease[2].

IC50 & Target

IC50: 2.39 µM- 28.12 µM (various strains of EV71)[2]

In Vitro

Brilliant black BN (E151) inhibits the interaction between EV71 and its cellular uncoating factor cyclophilin A [1].
Brilliant black BN (E151) inhibited the infection EV71 -GFP at a concentration of 300 µM as evidenced from the reduced GFP signals. Brilliant black BN (E151)exhibits the inhibition of EV71 -GFP as a dose-dependent manner in infected RD cells, exhibits an IC50 value of 10.1 µM[1].
Brilliant black BN (E151) is able to inhibit all tested 28 EV71, CVA16 and CVA6 strains. In rhabdomyosarcoma cells, 50% inhibitory concentration 29 of the dye E151 for various strains of EV71 ranged from 2.39 µM to 28.12 µM ,whereas its 50% cytotoxic concentration is 1870 µM [1].

In Vivo

Brilliant black BN (E151)(intraperitoneal injection; 200 mg/kg; 14 days)exhibits mild illness with clinical scores less than 3 and subsequently recovered when compared with PBS-group.All E151 270 treated mice are completely protected throughout the experiment[1].

Animal Model: 14-days old AG129 mice with EV71[1]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection
Result: Had a Protective eddect on EV71 challenged AG129 mice by dye E151.
Molecular Weight

867.68

Formula

C₂₈H₁₇N₅Na₄O₁₄S₄

CAS No.

2519-30-4

SMILES

O=S(C1=C2C=C(S(=O)(O[Na])=O)C(/N=N/C3=C4C=C(S(=O)(O[Na])=O)C=CC4=C(/N=N/C5=CC=C(S(=O)(O[Na])=O)C=C5)C=C3)=C(O)C2=C(NC(C)=O)C=C1)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (144.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1525 mL 5.7625 mL 11.5250 mL
5 mM 0.2305 mL 1.1525 mL 2.3050 mL
10 mM 0.1152 mL 0.5762 mL 1.1525 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Brilliant Black BNE 151E151E-151EnterovirusRhinovirusHRVHRVsHEVHEVsEV71,infectionHFMDantiviral,foodadditive,contagiousdiseaseInhibitorinhibitorinhibit

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Brilliant Black BN
Cat. No.:
HY-128382
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