L-6

By Targets:	ADC Linker (2) AMPK (1) Antibiotic (1) Apoptosis (2) Bacterial (2) Bcl-2 Family (1) Caspase (1) Endogenous Metabolite (1) Glutaminase (1) Influenza Virus (1) Interleukin Related (1) NF-κB (1) NOD-like Receptor (NLR) (1) Parasite (7) PERK (1) Phosphatase (1) Porcupine (1) Prostaglandin Receptor (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (2) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (5) Infection (9) Inflammation/Immunology (2) Metabolic Disease (4) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W082785A

L6H21	TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species	Neurological Disease Metabolic Disease Inflammation/Immunology
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low K_D value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and *IL-6* in RAW264.7 macrophages, with IC₅₀ values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .

HY-108357

6-Diazo-5-oxo-L-nor-Leucine 5+ Cited Publications L-6-Diazo-5-oxonorleucine; DON	Glutaminase Bacterial Influenza Virus Antibiotic	Infection Cancer
6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity .

HY-15825

IWP L6

2 Publications Verification

Porcn Inhibitor III
Porcupine Cancer

IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC₅₀ of 0.5 nM.

IWP L6 2 Publications Verification Porcn Inhibitor III	Porcupine	Cancer
IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC₅₀ of 0.5 nM.

HY-147537

Antileishmanial agent-9	Parasite	Infection
Antileishmanial agent-9 (compound 16c) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 4.01 μM. Antileishmanial agent-9 has relatively low cytotoxicity in L-6 cells (IC₅₀ = 40.1 μM) .

HY-147536

Antileishmanial agent-8	Parasite	Infection
Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC₅₀=73.9 μM) .

HY-155718

fac-[Re(CO)3(L6)(H2O)][NO3]	Apoptosis	Cancer
fac-[Re(CO)3(L6)(H2O)][NO3] (compound 6), the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re(CO)3(L6)(H2O)][NO3] is cytotoxic to prostate cancer cells, IC₅₀=50 nM (PC-3 cells). fac-[Re(CO)3(L6)(H2O)][NO3] mainly accumulates in the nucleus, down-regulates ATP production in PC3 cells, and promotes apoptosis. However, fac-[Re(CO)3(L6)(H2O)][NO3] did not induce necrosis, pyrodeath and autophagy .

HY-137908

11β-Misoprostol	Others	Others
11β-Misoprostol is one of several impurities which are possible in the production of Misoprostol. Misoprostol is a 15-deoxy-l6-hydroxy-l6-methyl analog of prostaglandin El (PGE1) .

HY-142088

Beauverolide Ka	Endogenous Metabolite	Metabolic Disease
Beauverolide Ka, a cyclotetradepsipeptide, is a metabolite of Beauveria bassiana fungus. Beauverolide Ka stimulates glucose uptake in cultured rat L6 myoblasts at 50 μM. Beauverolide Ka exhibits protecting effects on HEI-OC1 cells at 10 μM and shows dose-dependent activity in both L6 myoblasts and myotubes .

HY-N7572

Eupatoriopicrin	Parasite	Infection
Eupatoriopicrin is an antitrypanosomic agent with an IC₅₀ value of 1.2 μM (T. b. rhodesiense). Eupatoriopicrin is cytotoxic to L6 cells with an IC₅₀ value of 1.6 μM .

HY-129359

PDP-Pfp

ADC Linker Cancer

PDP-Pfp is a reducible ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) .
HY-129372

PDdB-Pfp

ADC Linker Cancer

PDdB-Pfp is a cleavable ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) .

PDP-Pfp	ADC Linker	Cancer
PDP-Pfp is a reducible ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) .

PDdB-Pfp	ADC Linker	Cancer
PDdB-Pfp is a cleavable ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) .

HY-147535

Antileishmanial agent-7	Parasite	Infection
Antileishmanial agent-7 (compound 23) is a potent antileishmanial agent. Antileishmanial agent-7 shows antileishmanial activity against Leishmania donovani and L-6, with IC₅₀ values of 6.89 and 259 μM, respectively .

HY-147933

Antitrypanosomal agent 8	Parasite	Infection
Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against *Trypanosoma brucei* with an IC₅₀ value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC₅₀=80.95 μM) .

HY-147534

Antileishmanial agent-6	Parasite	Infection
Antileishmanial agent-6 (compound 8m) is a potent antileishmanial agent. Antileishmanial agent-6 shows antileishmanial and cytotoxic activity against Leishmania donovani and L-6, with IC₅₀ values of 0.54 and 10.2 μM, respectively .

HY-110198

ONO-8130	Prostaglandin Receptor PERK	Inflammation/Immunology
ONO-8130 is an orally active and selective prostanoid EP1 receptor antagonist. ONO-8130 blocks phosphorylation of ERK in the L6 spinal cord. ONO-8130 relieves bladder pain in mice with cyclophosphamide-induced cystitis. ONO-8130 can be used for interstitial cystitis research .

HY-153018

PTP1B-IN-22	Phosphatase	Metabolic Disease
PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes .

HY-N0930B

Galegine hydrochloride	AMPK Bacterial	Infection Metabolic Disease
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .

HY-124623

DNDI-8219	Parasite	Infection
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

HY-RS04863

FER1L6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FER1L6 Human Pre-designed siRNA Set A contains three designed siRNAs for FER1L6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FER1L6 Human Pre-designed siRNA Set A FER1L6 Human Pre-designed siRNA Set A

HY-RS15354

UBE2L6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UBE2L6 Human Pre-designed siRNA Set A contains three designed siRNAs for UBE2L6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UBE2L6 Human Pre-designed siRNA Set A UBE2L6 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-142088

Beauverolide Ka	Structural Classification Natural Products Microorganisms Source classification	Endogenous Metabolite
Beauverolide Ka, a cyclotetradepsipeptide, is a metabolite of Beauveria bassiana fungus. Beauverolide Ka stimulates glucose uptake in cultured rat L6 myoblasts at 50 μM. Beauverolide Ka exhibits protecting effects on HEI-OC1 cells at 10 μM and shows dose-dependent activity in both L6 myoblasts and myotubes .

HY-N7572

Eupatoriopicrin	Saussurea costus (Falc.) Lipsch. Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae	Parasite
Eupatoriopicrin is an antitrypanosomic agent with an IC₅₀ value of 1.2 μM (T. b. rhodesiense). Eupatoriopicrin is cytotoxic to L6 cells with an IC₅₀ value of 1.6 μM .

HY-N0930B

Galegine hydrochloride	Alkaloids Classification of Application Fields Leguminosae Source classification Metabolic Disease Plants Disease Research Fields Galega officinalis Linn.	AMPK Bacterial
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .

Species:	Human (5) Cynomolgus (1)
Tag:	His (4) Tag Free (1) GST (1) Flag (2)
Source:	HEK293 (3) P. pastoris (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P702595

	TM4SF1 Protein-VLP, Cynomolgus (HEK293, His) M3S1; TAAL6; H-L6; L6	Cynomolgus	HEK293
	TM4SF1 Protein-VLP, Cynomolgus (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays.

HY-P700837

TM4SF1 Protein-VLP, Human (HEK293)

M3S1; TAAL6; H-L6; L6
Human HEK293

TM4SF1 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay.

	TM4SF1 Protein-VLP, Human (HEK293) M3S1; TAAL6; H-L6; L6	Human	HEK293
	TM4SF1 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay.

HY-P71020

	UBE2L6 Protein, Human (His) Ubiquitin/ISG15-Conjugating Enzyme E2 L6; Retinoic Acid-Induced Gene B Protein; RIG-B; UbcH8; Ubiquitin Carrier Protein L6; Ubiquitin-Protein Ligase L6; UBE2L6; UBCH8	Human	E. coli
	The UBE2L6 protein plays a key role in cell regulation by catalyzing the covalent attachment of ubiquitin or ISG15 to other proteins. Notably, it plays a role in E6/E6-AP-induced ubiquitination of p53/TP53, a core process in regulating cellular responses to stress and DNA damage. UBE2L6 Protein, Human (His) is the recombinant human-derived UBE2L6 protein, expressed by E. coli , with C-6*His labeled tag. The total length of UBE2L6 Protein, Human (His) is 153 a.a., with molecular weight of ~17.0 kDa.

HY-P701329

	TM4SF1 Protein,Human (N-His) M3S1; Membrane component chromosome 3 surface marker 1; T4S1_HUMAN; TAAL6; Tm4sf1; Transmembrane 4 L6 family member 1; Tumor-associated antigen L6	Human	P. pastoris
	TM4SF1 protein-VLP is present in tumor cells and can form high molecular weight complexes, indicating its involvement in complex cellular processes in malignant tumors. It interacts with SDCBP2, emphasizing its association with specific molecular pathways, suggesting a role in cell signaling or regulatory mechanisms. TM4SF1 Protein,Human (N-His) is the recombinant human-derived TM4SF1 protein,Human, expressed by P. pastoris , with N-His labeled tag. The total length of TM4SF1 Protein,Human (N-His) is 47 a.a., with molecular weight of 7.3 kDa.

HY-P75983

	PRMT6 Protein, Human (HEK293, His-Flag) Protein arginine N-methyltransferase 6; PRMT6; HRMT1L6	Human	HEK293
	PRMT6, a versatile arginine methyltransferase, prefers asymmetrical dimethylarginine (aDMA) formation and methylates arginine residues within a glycine and arginine-rich domain. It orchestrates asymmetric dimethylation of histone H3 'Arg-2,' leading to H3R2me2a, a unique epigenetic tag associated with transcriptional repression. PRMT6 serves as a transcriptional repressor for various genes, including HOXA2, THBS1, and TP53, inhibiting cellular senescence by repressing TP53. It also methylates histones H2A and H4 'Arg-3,' acts as a coactivator for steroid hormone receptors, regulates alternative splicing, and plays a role in innate immunity against HIV-1. PRMT6 Protein, Human (HEK293, His-Flag) is the recombinant human-derived PRMT6 protein, expressed by HEK293, with N-Flag, C-His labeled tag. The total length of PRMT6 Protein, Human (HEK293, His-Flag) is 375 a.a., with molecular weight of 43-46 kDa.

HY-P702699

	CDK19-CCNC-MED12 Protein, Human (sf9, GST, Flag, His) CDC2L6; CDK19; cyclin dependent kinase 19; CDK11; CDC2L6; bA346C16.3; cyclin-dependent kinase 19; CDC2-related protein kinase 6; CDK8-like cyclin-dependent kinase; cell division cycle 2-like 6 (CDK8-like); cell division cycle 2-like protein kinase 6; cell division protein kinase 19; cyclin dependent kinase 19 variant 2; cyclin-dependent kinase (CDC2-like) 11; cyclin-dependent kinase 11; death-preventing kinase; EC 2.7.11.22	Human	Sf9 insect cells


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Cat. No.	Product Name	Application	Reactivity

HY-P80875

PRMT6 Antibody (YA685) HRMT1L6; PRMT 6	WB, IHC-F, IHC-P, ICC/IF	Human
PRMT6 Antibody (YA685) is a non-conjugated and Mouse origined monoclonal antibody about 42 kDa, targeting to PRMT6 (2C3). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

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L-6

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