2. Metabolic Enzyme/Protease Anti-infection
  3. Glutaminase Bacterial Influenza Virus Antibiotic
  4. 6-Diazo-5-oxo-L-nor-Leucine

6-Diazo-5-oxo-L-nor-Leucine  (Synonyms: DON; L-6-Diazo-5-oxonorleucine; 6-ジアゾ-5-オキソ-L-ノルロイシン)

製品番号: HY-108357 純度: 99.98%
COA 取扱説明書 Technical Support

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity.

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CAS 番号 : 157-03-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 165 在庫あり
Solution
10 mM * 1 mL in Water USD 165 在庫あり
Solid
1 mg $50 在庫あり
5 mg $150 在庫あり
10 mg $240 在庫あり
25 mg $480 在庫あり
50 mg $770 在庫あり
100 mg $1230 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 14 publication(s) in Google Scholar

Other Forms of 6-Diazo-5-oxo-L-nor-Leucine:

6-Diazo-5-oxo-L-nor-Leucine 関連抗体

Top Publications Citing Use of Products

    6-Diazo-5-oxo-L-nor-Leucine purchased from MedChemExpress. Usage Cited in: Front Immunol. 2022 May 19:13:880262.  [Abstract]

    Splenocytes treated with 6-Diazo-5-oxo-L-nor-Leucine (DON; 2.5 µM; 24 h) has lower expressions of CD25 and CD69 in CD4(+) T cells.

    6-Diazo-5-oxo-L-nor-Leucine purchased from MedChemExpress. Usage Cited in: Front Immunol. 2022 May 19:13:880262.  [Abstract]

    Splenocytes treated with 6-Diazo-5-oxo-L-nor-Leucine (DON; 2.5 µM; 24 h) has lower expressions of CD25 and CD69 in CD8(+) T cells.

    6-Diazo-5-oxo-L-nor-Leucine purchased from MedChemExpress. Usage Cited in: Front Immunol. 2022 May 19:13:880262.  [Abstract]

    6-Diazo-5-oxo-L-nor-Leucine (DON; 2.5 µM; 24 h) inhibits the the levels of phosphorylated mTOR and P70S6K (ConA-induced) in splenocytes.

    Antibiotic アイソフォーム固有の製品をすべて表示:

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    製品説明

    6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity[1][2][3].

    IC50 & Target

    Bacterial[3].
    体外実験

    6-Diazo-5-oxo-L-nor-Leucine (DON) (0.3 mM; 1 h) shows inhibition of glutamine catabolism in WI-L2 cells[1].
    6-Diazo-5-oxo-L-nor-Leucine (DON) decreases the selfrenewal potential and metastatic ability of tumor cell[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    6-Diazo-5-oxo-L-nor-Leucine 関連抗体

    Cell Viability Assay[1]

    Cell Line: WI-L2 cells
    Concentration: 0.3 mM
    Incubation Time: 1 h
    Result: Inhibited the rapid catabolism of glutamine by the cultured human lymphoblast line WI-L2 greater than 95%.
    体内実験

    6-Diazo-5-oxo-L-nor-Leucine sensitizes pancreatic tumors to anti-PD1 resulting in tumor regression and prolonged survival in vivo[2].
    6-Diazo-5-oxo-L-nor-Leucine decreases hyaluronan and collagen in the tumor microenvironment, leading to an extensive remodeling of the ECM (extensive extracellular matrix), and an increases infiltration CD8+ T-cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    171.15

    分子式

    C6H9N3O3
    CAS 番号
    Appearance

    Solid

    Color

    Off-white to light brown

    SMILES

    N[C@@H](CCC(C=[N+]=[N-])=O)C(O)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 25 mg/mL (146.07 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.8428 mL 29.2141 mL 58.4283 mL
    5 mM 1.1686 mL 5.8428 mL 11.6857 mL
    10 mM 0.5843 mL 2.9214 mL 5.8428 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    一般には略語で表示されます：C1V1 = C2V2

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    純度とドキュメンテーション

    純度: 99.98%

    COA (244 KB) HNMR (243 KB) RP-HPLC (259 KB) MS (68 KB) OR (293 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.8428 mL 29.2141 mL 58.4283 mL 146.0707 mL
    5 mM 1.1686 mL 5.8428 mL 11.6857 mL 29.2141 mL
    10 mM 0.5843 mL 2.9214 mL 5.8428 mL 14.6071 mL
    15 mM 0.3895 mL 1.9476 mL 3.8952 mL 9.7380 mL
    20 mM 0.2921 mL 1.4607 mL 2.9214 mL 7.3035 mL
    25 mM 0.2337 mL 1.1686 mL 2.3371 mL 5.8428 mL
    30 mM 0.1948 mL 0.9738 mL 1.9476 mL 4.8690 mL
    40 mM 0.1461 mL 0.7304 mL 1.4607 mL 3.6518 mL
    50 mM 0.1169 mL 0.5843 mL 1.1686 mL 2.9214 mL
    60 mM 0.0974 mL 0.4869 mL 0.9738 mL 2.4345 mL
    80 mM 0.0730 mL 0.3652 mL 0.7304 mL 1.8259 mL
    100 mM 0.0584 mL 0.2921 mL 0.5843 mL 1.4607 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    6-Diazo-5-oxo-L-nor-Leucine Related Classifications

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    一般には略語で表示されます：C1V1 = C2V2

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    Keywords:

    6-Diazo-5-oxo-L-nor-Leucine157-03-9L-6-Diazo-5-oxonorleucine DONGlutaminaseBacterialInfluenza VirusAntibioticpancreatic cancercancerantitumourWI-L2CD8+ T-cellsanti-PD1bacterialvirusInhibitorinhibitorinhibit

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    製品番号:
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