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V-9302 

Cat. No.: HY-112683 Purity: 98.91%
Handling Instructions

V-9302 is a competitive antagonist of transmembrane glutamine flux. V-9302 selectively and potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells.

For research use only. We do not sell to patients.

V-9302 Chemical Structure

V-9302 Chemical Structure

CAS No. : 1855871-76-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 107 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 285 In-stock
Estimated Time of Arrival: December 31
50 mg USD 510 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

V-9302 is a competitive antagonist of transmembrane glutamine flux. V-9302 selectively and potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells[1].

IC50 & Target

ASCT2[1]

In Vitro

V-9302 inhibits ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibits a 100-fold improvement in potency over gamma-L-glutamyl-p-nitroanilide[1].
Pharmacological blockade of ASCT2 with V-9302 results in attenuated cancer cell growth and proliferation, increases cell death, and increases oxidative stress[1].

In Vivo

V-9302 (75 mg/kg; i.p.; daily fo 21 days) prevents tumor growth in both HCT-116 and HT29 xenograft models[1].

Animal Model: 6-week old, female athymic nude mice (bearing HCT-116 (KRAS G13D) or HT29 (BRAF V600E) cell-line)[1]
Dosage: 75 mg/kg
Administration: Intraperitoneally; daily fo 21 days
Result: Prevented tumor growth.
Molecular Weight

538.68

Formula

C₃₄H₃₈N₂O₄

CAS No.

1855871-76-9

SMILES

O=C(O)[[email protected]@H](N)CCN(CC1=CC=CC=C1OCC2=CC=CC(C)=C2)CC3=CC=CC=C3OCC4=CC=CC(C)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (232.05 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8564 mL 9.2819 mL 18.5639 mL
5 mM 0.3713 mL 1.8564 mL 3.7128 mL
10 mM 0.1856 mL 0.9282 mL 1.8564 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.91%

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Keywords:

V-9302V9302V 9302OthersglutamineuptakefluxtransporterproliferationoxidativestressathymicnudemiceHEK-293Inhibitorinhibitorinhibit

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Product name:
V-9302
Cat. No.:
HY-112683
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